ID Q5KIE9_CRYNJ Unreviewed; 404 AA.
AC Q5KIE9; Q55TZ0;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Ran GTPase activator, putative {ECO:0000313|EMBL:AAW43201.1};
GN OrderedLocusNames=CND03210 {ECO:0000313|EMBL:AAW43201.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43201.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43201.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017344; AAW43201.1; -; Genomic_DNA.
DR RefSeq; XP_570508.1; XM_570508.1.
DR AlphaFoldDB; Q5KIE9; -.
DR STRING; 214684.Q5KIE9; -.
DR PaxDb; 214684-Q5KIE9; -.
DR EnsemblFungi; AAW43201; AAW43201; CND03210.
DR GeneID; 3256990; -.
DR KEGG; cne:CND03210; -.
DR VEuPathDB; FungiDB:CND03210; -.
DR eggNOG; KOG1909; Eukaryota.
DR HOGENOM; CLU_028747_3_0_1; -.
DR InParanoid; Q5KIE9; -.
DR OMA; NGSMEAW; -.
DR OrthoDB; 2785778at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0006606; P:protein import into nucleus; IEA:EnsemblFungi.
DR GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0006404; P:RNA import into nucleus; IEA:EnsemblFungi.
DR GO; GO:0006407; P:rRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0031509; P:subtelomeric heterochromatin formation; IEA:EnsemblFungi.
DR GO; GO:0006409; P:tRNA export from nucleus; IEA:EnsemblFungi.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027038; RanGap.
DR PANTHER; PTHR24113; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR24113:SF5; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00368; LRR_RI; 8.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 334..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 43970 MW; F1BC434FC8DB3C15 CRC64;
MSKVFSILGK NLKANTKAEL EPYISQLEEM EDVEEVHFGG NSLGVEACEA IASVLKKKTN
LKVVDLADIF TGRLISEIPQ ALSALCNALS DHTSLVELDL SDNAFGGRCA DALVPFLQSN
THFQIFKLNN NGLGPWGGSV VAKALLDNAA KCEKEGKESS LKVVVCGRNR LENGSAPDWA
EAFGKHRNLK EVKMPQNGIR MEGIQALAEG LSNCKELEHL DLQDNTATKT GTRAIVKHLG
SWPNLKHLNL SDCLLGSAGG IALATSLSLG SNPKLESLKL QYGEMDKRAI ELLSVAISQH
LKELTVLELN GNRFSEDDEC VEELKKALEL WGHEEALDEL DDMEEPESEE EESEKEEERE
EEETGEPDDG VDKGASGEDK LPPASDKQTD ELADMLAGVH VGKQ
//
