ID Q5KJQ6_CRYNJ Unreviewed; 639 AA.
AC Q5KJQ6; Q55WI9;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Ferroxidase, putative {ECO:0000313|EMBL:AAW42479.1};
GN OrderedLocusNames=CNC05690 {ECO:0000313|EMBL:AAW42479.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42479.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42479.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR EMBL; AE017343; AAW42479.1; -; Genomic_DNA.
DR RefSeq; XP_569786.1; XM_569786.1.
DR AlphaFoldDB; Q5KJQ6; -.
DR STRING; 214684.Q5KJQ6; -.
DR PaxDb; 214684-Q5KJQ6; -.
DR EnsemblFungi; AAW42479; AAW42479; CNC05690.
DR VEuPathDB; FungiDB:CNC05690; -.
DR eggNOG; KOG1263; Eukaryota.
DR HOGENOM; CLU_006504_7_3_1; -.
DR InParanoid; Q5KJQ6; -.
DR OMA; GHNFQIV; -.
DR OrthoDB; 449862at2759; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0033573; C:high-affinity iron permease complex; IBA:GO_Central.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004322; F:ferroxidase activity; IBA:GO_Central.
DR GO; GO:0010106; P:cellular response to iron ion starvation; IBA:GO_Central.
DR GO; GO:0033215; P:reductive iron assimilation; IBA:GO_Central.
DR CDD; cd13851; CuRO_1_Fet3p; 1.
DR CDD; cd13877; CuRO_2_Fet3p_like; 1.
DR CDD; cd13899; CuRO_3_Fet3p; 1.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 3.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR001117; Cu-oxidase_2nd.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR045087; Cu-oxidase_fam.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR044130; CuRO_2_Fet3-like.
DR PANTHER; PTHR11709:SF361; IRON TRANSPORT MULTICOPPER OXIDASE FET3; 1.
DR PANTHER; PTHR11709; MULTI-COPPER OXIDASE; 1.
DR Pfam; PF00394; Cu-oxidase; 1.
DR Pfam; PF07731; Cu-oxidase_2; 1.
DR Pfam; PF07732; Cu-oxidase_3; 1.
DR SUPFAM; SSF49503; Cupredoxins; 3.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 1.
DR PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..639
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004258405"
FT DOMAIN 29..146
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 158..328
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF00394"
FT DOMAIN 392..525
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
SQ SEQUENCE 639 AA; 70646 MW; 5F2DD279E7F1F0E0 CRC64;
MPRLSSLFLA SATAASVAMA AVHDLYWNIT YATANPDQLH NKTQAIGVNG TWPPPPIVVN
QGDTLTVHAF NGLESVGTTL HSHGNYFNGS NYYDGAAAVT QCPIPPGETL VYEIPVNDQW
GTYWIHGHYK GQYVDGLRAP LIIMPNETNE RTDITWDEDF TIIMGDWYHD TSPYLVSSYF
LNWVNPTGAE PVPDSVTFYV MNTTSGEYLS SNVAQGVDVT ADVNNNAAIP FEPGKKYRIR
FINMSALSML HIYMGGHTFD IIEVDAVDIE PYQSANLTIS VAQRYSVLVE ALNTTDANYA
IMFYQDTDMY DTVPDTLAVN NSVTLQYDAS LGPADMFNIT DDTWPILDDT RFVPLQAKGS
AEADVSYELG AYFDTFDDGT NRAAFNNVTY VMPTTPSLFT QLSMGTDAWD TRIYGQQTHA
LMMPHLEMIE LVIVNWDTGY HPFHLHGHEF QIMGKSFDVT SNDSSINPPV LENQSNPARR
DTIMVPPGGS VHIRFRADNP GAWIFHCHID WHMDSGLAVI MITDPSYSQS KLEIPQTMKD
HCAYWGYSAT GNVVGLNSTT DFKGEAVGPF PLVMGWTTKA KGALAGCIIA ALAGFASVVW
YGAEHLDEEE IEAEIRRKAE IKAASGGKFG MIKKVVKRE
//
