ID Q5KKZ7_CRYNJ Unreviewed; 1121 AA.
AC Q5KKZ7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=DUF726-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CNC01300 {ECO:0000313|EMBL:AAW42140.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42140.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42140.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017343; AAW42140.1; -; Genomic_DNA.
DR RefSeq; XP_569447.1; XM_569447.1.
DR AlphaFoldDB; Q5KKZ7; -.
DR STRING; 214684.Q5KKZ7; -.
DR ESTHER; cryne-q5kkz7; Duf_726.
DR PaxDb; 214684-Q5KKZ7; -.
DR EnsemblFungi; AAW42140; AAW42140; CNC01300.
DR GeneID; 3256418; -.
DR KEGG; cne:CNC01300; -.
DR VEuPathDB; FungiDB:CNC01300; -.
DR eggNOG; KOG2385; Eukaryota.
DR HOGENOM; CLU_001695_0_0_1; -.
DR InParanoid; Q5KKZ7; -.
DR OMA; AIQNMEL; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007941; DUF726.
DR InterPro; IPR029024; TerB-like.
DR PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF158682; TerB-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 585..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1028..1055
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 122634 MW; E596D5D30E615311 CRC64;
MIPSPRRAAS TPAVQTWPDL DDDDGWQDMP VVRSDSNPFG LDEEDQKKYH YRTSISLDDD
PAGPSGTGNA TGKHLELEAD TLATDSWREK VEQDESDYTR IRLDEDEESE EVHMRTKYLF
NEDKAMTPLS QMQTTKELLT EGQRIAYVAL CHLIMKRMLR DMGRGWEGYK AKNKLGVKGK
GKAEVPVVES GHIWMLKLMA RLYQHMELTK DEQRMIESLA EHGVDPSDLV PALMTTHTVN
NPDFDPKEKE RVDLEEALRK EAEADDEAER EAKAEEERHV VVEDQGASDT ETEPPPPYEV
EERSISFAAS PMGKKASSSS LELLSKSINP FGFDDDDVPK PLLGTKSPLS EGSFPNDSST
IISPQANVNP FGSDDENEGS LAVSEIRAPG AQSKAQTLSS FEKDEGDIGG AHSSPFSEPS
NSPLDAAFAS TADRPTPCRP QSLQTEDASQ STSDATEKPS VDTKLTPKDE PVTLFDAADP
QAPALLPALP GVSTSLSTTD EHVTLDIRWT VLCDLFLVLI ADSVFDARSR AFLVRVAAAL
GFDWLDVVRF ENRVTEALEI QEGMEKKGQH EIIEGRRKAA RNKRYAMMGL AAVGGGLVIG
LSAGLMAPFI GAGLGTAFAT VGITGTTGFL AGAGGAAVIT TGGVLTGANI AGKGMARRTR
EVRIFELKPL HNDKRVNCYI TMGGFMASKV DDVRLPFSVL DPVVGDVFSV LWEPEMMAEM
GNALKILTSE ILTQVGQQVL QATVMTALMS ALQWPLILTK LGYLIDNPWS NALDRARAAG
LVLADVIIQR HAGVRPISLI GFSLGARAIF YALIELARQK AYGLVQEVFI FGTTVTASRD
TWLDVRSVVA GRFVNGYATN DWMLGYLFRA TSGGLNTVAG LRPVETVWGL ENVDVTEIIT
GHMSYRSCMP QLLAKVGFPV TADYFDEPDD PEIDMNVQER TVVDEAEEEA KRNHKKVLGI
FPVKKNRSSG SGHNTPTTEK HSGASTPNPS VSQAAAGEYE LEDDDLPPRE EVDIGQMASE
KDTSTPVEEE KELEIKAVKQ REEEEQKERE AIQAIPKTAG FDFQAISREL GKDIDVDKLK
EPEPRYFPPA LMEIRAPLER SGSAPPPTSF VPPPAEKNVW V
//
