ID Q5KLC6_CRYNJ Unreviewed; 423 AA.
AC Q5KLC6; Q55YL2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 102.
DE SubName: Full=Racemase, putative {ECO:0000313|EMBL:AAW42009.1};
GN OrderedLocusNames=CNB05750 {ECO:0000313|EMBL:AAW42009.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42009.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42009.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AE017342; AAW42009.1; -; Genomic_DNA.
DR RefSeq; XP_569316.1; XM_569316.1.
DR AlphaFoldDB; Q5KLC6; -.
DR STRING; 214684.Q5KLC6; -.
DR PaxDb; 214684-Q5KLC6; -.
DR EnsemblFungi; AAW42009; AAW42009; CNB05750.
DR GeneID; 3255820; -.
DR KEGG; cne:CNB05750; -.
DR VEuPathDB; FungiDB:CNB05750; -.
DR eggNOG; ENOG502QRKX; Eukaryota.
DR HOGENOM; CLU_030273_1_1_1; -.
DR InParanoid; Q5KLC6; -.
DR OMA; WGYAELR; -.
DR OrthoDB; 33243at2759; -.
DR Proteomes; UP000002149; Chromosome 2.
DR GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR GO; GO:0050032; F:L-rhamnonate dehydratase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR GO; GO:0016052; P:carbohydrate catabolic process; IBA:GO_Central.
DR CDD; cd03327; MR_like_2; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR023444; L-Rhamnon_dehydrat.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR InterPro; IPR046945; RHMD-like.
DR PANTHER; PTHR13794; ENOLASE SUPERFAMILY, MANDELATE RACEMASE; 1.
DR PANTHER; PTHR13794:SF58; MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDF00006; rhamnonate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 170..268
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 423 AA; 46867 MW; 1A2291E54C3F17C1 CRC64;
MPKQWPTIVK LETFIPSAHG SGGDYHRQGG DHWIVQGNIS CPMHKYEEYK VSRTSWGIGV
LGSIFVKVHA SDGTVGYATG FGGPPACWLI EEHFKRFIVG QDPRDTNKMW DQMFRASMFY
GRKGLPLAAI SVVDLAIWDL LGKIRGEPIY KMIGGRTKKD IPLYLTGPRP EVAKKLGFWG
SKVALPHGPP DGHEGIRKNV EYLKACKEAV GPDYPVQVDC YMSLDVPYTI ALVKACEKAG
VEINWWEEVL HPDDFDGHIK LKEALPYVKF TTGEHEYSKY GFRKLIENRA VDIIQPDVMW
LGGLTELIKV AAMAAAYDIP VVPHGSGPYS FQAIMSFPNS DFCEYIANSP DGKSIEPSFG
NLFLNEVLPR NGRVDLTDEP GFGLELNPSA ELVPYKSFFT PSKSLGAAGE VEDDGKAKVN
GKH
//
