ID Q5KLL7_CRYNJ Unreviewed; 548 AA.
AC Q5KLL7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Transcriptional activator, putative {ECO:0000313|EMBL:AAW41665.1};
GN OrderedLocusNames=CNB04820 {ECO:0000313|EMBL:AAW41665.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41665.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41665.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MEF2 family.
CC {ECO:0000256|ARBA:ARBA00025805}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017342; AAW41665.1; -; Genomic_DNA.
DR RefSeq; XP_568972.1; XM_568972.1.
DR AlphaFoldDB; Q5KLL7; -.
DR STRING; 214684.Q5KLL7; -.
DR PaxDb; 214684-Q5KLL7; -.
DR EnsemblFungi; AAW41665; AAW41665; CNB04820.
DR GeneID; 3256082; -.
DR KEGG; cne:CNB04820; -.
DR VEuPathDB; FungiDB:CNB04820; -.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_496073_0_0_1; -.
DR InParanoid; Q5KLL7; -.
DR OMA; ISAGHHQ; -.
DR OrthoDB; 448298at2759; -.
DR Proteomes; UP000002149; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; Transcription factor, MADS-box; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR PANTHER; PTHR48019:SF93; SERUM RESPONSE FACTOR; 1.
DR PANTHER; PTHR48019; SERUM RESPONSE FACTOR HOMOLOG; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SRF-like; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000259|PROSITE:PS50066"
FT REGION 90..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 59350 MW; C8DA81E885C15A18 CRC64;
MGRKKIEIRP LTDERNRNVT FLKRKAGLMK KAWELSVLCA ADVSIIIFSA AGKAFEFSSK
ELDSEIDRYH DYEGMIERRR AAEFAAMALA GEDDDDDEDD DTSRRGSASK SKAAAAANGN
PPPTRSLKGK ETFKHRTVRP GEDRKRKRQD KKQRRKSEPS EKRSFIDEIM SGGESDSEEE
EKPRRRSNAE HGNGKRMSSL REEDELADDV PHASRQSLDG LQYALSMHAS QPSFERFASR
HRSPHAEFLA PAASSSQTPL TTPTIHRHPS DTIPYPMTNS LAAAPMQASL GVPQLGVHPS
YPHNPNGHPG YLGYPKSLLG MQASYLPRQP FADAPQPSPY YGAQGPGSHP GGPPQPGLPT
QMPGGQPIQW DQNLLARYAE FQLQQNHQRQ QRILLERQRQ QLAELGVPLD EKNLLDEIFG
GVGASRSVSG GADPSGAGPG SALLTGLGNT ASEGREEGNS LEFIWPLGNN AAAAAPISDE
DRNDVSSRSV ISAGHHQAAY GYGKPHVQQQ KTGWGFDGAG FESMEEVASG SGVGLPSPVS
AGAGGGRK
//
