ID Q5KN45_CRYNJ Unreviewed; 847 AA.
AC Q5KN45; Q55YS6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 112.
DE RecName: Full=Ricin B lectin domain-containing protein {ECO:0000259|SMART:SM00458};
GN OrderedLocusNames=CNA07770 {ECO:0000313|EMBL:AAW41305.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41305.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41305.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
CC {ECO:0000256|ARBA:ARBA00005641}.
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DR EMBL; AE017341; AAW41305.1; -; Genomic_DNA.
DR RefSeq; XP_567124.1; XM_567124.1.
DR AlphaFoldDB; Q5KN45; -.
DR SMR; Q5KN45; -.
DR STRING; 214684.Q5KN45; -.
DR CAZy; CBM13; Carbohydrate-Binding Module Family 13.
DR CAZy; GH5; Glycoside Hydrolase Family 5.
DR PaxDb; 214684-Q5KN45; -.
DR EnsemblFungi; AAW41305; AAW41305; CNA07770.
DR GeneID; 3253596; -.
DR KEGG; cne:CNA07770; -.
DR VEuPathDB; FungiDB:CNA07770; -.
DR eggNOG; ENOG502SFRC; Eukaryota.
DR HOGENOM; CLU_355650_0_0_1; -.
DR InParanoid; Q5KN45; -.
DR OMA; WRDDAFT; -.
DR OrthoDB; 1465096at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0008422; F:beta-glucosidase activity; IBA:GO_Central.
DR GO; GO:0009251; P:glucan catabolic process; IBA:GO_Central.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR001547; Glyco_hydro_5.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR31297:SF41; ENDOGLUCANASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01830)-RELATED; 1.
DR PANTHER; PTHR31297; GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B; 1.
DR Pfam; PF00150; Cellulase; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..847
FT /note="Ricin B lectin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004257918"
FT DOMAIN 26..152
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT REGION 284..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 91055 MW; 72C0B7468F52F024 CRC64;
MSAFTYTAAL FSLISLLPSA LAGPTAGTTY SVSPNQHPSM CLAPANNWEG ADVVLKDCDE
DDTTWLWTGQ SFQNTATDLC IDIRDYGAWS GNKAQVWGCF SYNTNQQFTV EESMIHWDNF
CWDLTDGSSS AGTMLQIWSC YSYNDNQQWT LTEIEEVDEC DATSVTETAT IMSTATASVS
DLSTATASVS ASNITEAVTA TESLTASVNA TDPFFTASAT DSGYQVNATA SATYSSYDVN
ATASATDSGY ESINVTASAT ESGYEFVNAT ASATLSAETS TATNSSIGEG LWSPHKSSSV
SSDDWSSETA TRSNTEWWAT STGSDSWASA TASASNPGQN ASQSDSWNAT STASNPWETA
SSQASNETST DSWGASATAT ASQSDSWDAT STASNPWETA SSSQAWNETS TDSWGASATA
TATESGSYGN ATSTSTSSAI TATATVGTIS SGYLQTSGTK IVDSDGNEVI LRGTNIGGWL
VLEDWMCGIT DTSGSSDRFS LSTLENRFGT DQARTLVEAW AENWLTTSDF DELAAIGFNV
IRLPFSFRTV QNADGSWRDD AFTRMDWAIS QAKARGIYTI VDFHMWSGQE ADYSAISENT
DEGQSQRDAA GEIWKKVATH YLGESSICAF DVINEPTGSY GDYLQQDLYN AVRSVDANRI
IIHESISTDP STYGWTNVIY SLHEYDMMGS DLSSNQATWT NGVQAYIDLW HGYNIPFMLA
EFMADGETLD YMLNSMNSQG ISWLTWAHST VNMGRWGIWN HEAFNVDVSS DSYDTIYSAW
TNMPSTFHTS IYDQMKTAAT GSTNVSSRKR DLASAARATK RFHGSHGGRS RRNGMAHAVR
GAAGVSI
//
