ID Q5KNG6_CRYNJ Unreviewed; 315 AA.
AC Q5KNG6; Q55Z51;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Urease accessory protein ureG, putative {ECO:0000313|EMBL:AAW41177.1};
GN OrderedLocusNames=CNA06560 {ECO:0000313|EMBL:AAW41177.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41177.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41177.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC subfamily. {ECO:0000256|ARBA:ARBA00005732}.
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DR EMBL; AE017341; AAW41177.1; -; Genomic_DNA.
DR RefSeq; XP_566996.1; XM_566996.1.
DR AlphaFoldDB; Q5KNG6; -.
DR STRING; 214684.Q5KNG6; -.
DR PaxDb; 214684-Q5KNG6; -.
DR EnsemblFungi; AAW41177; AAW41177; CNA06560.
DR GeneID; 3253927; -.
DR KEGG; cne:CNA06560; -.
DR VEuPathDB; FungiDB:CNA06560; -.
DR eggNOG; ENOG502QR6E; Eukaryota.
DR HOGENOM; CLU_072144_0_0_1; -.
DR InParanoid; Q5KNG6; -.
DR OMA; KMRGDKP; -.
DR OrthoDB; 5484572at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0019627; P:urea metabolic process; IEA:EnsemblFungi.
DR CDD; cd05540; UreG; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01389; UreG; 1.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004400; UreG.
DR NCBIfam; TIGR00101; ureG; 1.
DR PANTHER; PTHR31715; UREASE ACCESSORY PROTEIN G; 1.
DR PANTHER; PTHR31715:SF0; UREASE ACCESSORY PROTEIN G; 1.
DR Pfam; PF02492; cobW; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nickel insertion {ECO:0000256|ARBA:ARBA00022988};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 113..281
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT REGION 28..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 33899 MW; 0F0AF620FAE5CA57 CRC64;
MAAPAQPSSP PPVCQFSDRL TTALNAAQDA TGTDSPHAHH HHTPSALSGA SSVISHNHDN
MSHDHGHFHD HGPGLWTPEE HGHTHEHLEH AGKFAERDMP DYTGRNWTER AFTVGIGGPV
GSGKTALLLA LCRGFREKYN IAAVTNDIFT REDQEFLIRN EALPAERIRA IETGGCPHAA
IREDISANMG ALEKLQAEFD TEMLFVESGG DNLAANYSRE LADYIIYVID VSGGDKIPRK
GGPGITQSDL LIVNKIDLAP YVGASLDVMR RDAAAMRGSG PTLFTSVRNN DGVDAVMDII
VSAWRASQGS GKARA
//
