ID Q5KNG8_CRYNJ Unreviewed; 213 AA.
AC Q5KNG8; Q55Z53;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=Vacuolar protein sorting-associated protein 28 {ECO:0000256|PIRNR:PIRNR017535};
DE AltName: Full=ESCRT-I complex subunit VPS28 {ECO:0000256|PIRNR:PIRNR017535};
GN OrderedLocusNames=CNA06540 {ECO:0000313|EMBL:AAW41175.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41175.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41175.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Component of the ESCRT-I complex (endosomal sorting complex
CC required for transport I), a regulator of vesicular trafficking
CC process. {ECO:0000256|PIRNR:PIRNR017535}.
CC -!- SIMILARITY: Belongs to the VPS28 family.
CC {ECO:0000256|PIRNR:PIRNR017535, ECO:0000256|PROSITE-ProRule:PRU00642}.
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DR EMBL; AE017341; AAW41175.2; -; Genomic_DNA.
DR RefSeq; XP_566994.1; XM_566994.1.
DR AlphaFoldDB; Q5KNG8; -.
DR STRING; 214684.Q5KNG8; -.
DR PaxDb; 214684-Q5KNG8; -.
DR EnsemblFungi; AAW41175; AAW41175; CNA06540.
DR VEuPathDB; FungiDB:CNA06540; -.
DR eggNOG; KOG3284; Eukaryota.
DR HOGENOM; CLU_076417_0_1_1; -.
DR InParanoid; Q5KNG8; -.
DR OrthoDB; 5486880at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR GO; GO:0006612; P:protein targeting to membrane; IEA:EnsemblFungi.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:EnsemblFungi.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR Gene3D; 1.20.120.1130; -; 1.
DR Gene3D; 1.20.1440.200; -; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR007143; Vps28.
DR InterPro; IPR017899; VPS28_C.
DR InterPro; IPR037206; VPS28_C_sf.
DR InterPro; IPR017898; VPS28_N.
DR InterPro; IPR038358; VPS28_N_sf.
DR PANTHER; PTHR12937; VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28; 1.
DR PANTHER; PTHR12937:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG; 1.
DR Pfam; PF03997; VPS28; 1.
DR PIRSF; PIRSF017535; VPS28; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF140427; VPS28 C-terminal domain-like; 1.
DR PROSITE; PS51310; VPS28_C; 1.
DR PROSITE; PS51313; VPS28_N; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753, ECO:0000256|PIRNR:PIRNR017535};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR017535};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR017535}.
FT DOMAIN 1..103
FT /note="VPS28 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51313"
FT DOMAIN 113..208
FT /note="VPS28 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51310"
SQ SEQUENCE 213 AA; 24241 MW; 6F3756E8D451F427 CRC64;
MMNLDEEVRL WTTNAEREKT ENLATLYSII VSLEYLERAY VRDSVSGKEY APACLKLLAQ
YKSLMKLVAD DIGGVEAFMK RFKMDHPAAL HRLTVGVPAT VEHSAEAEDG GAEKGKWVAE
TTQSFITFMD ALKLNLKAKD QLHPFLTELM SGYSRFKGSQ EWEGRGKILH WLIELNAMKA
SDEISEEQSR QMLFDIENAY NEFFRSLSNS KGD
//
