ID Q5KPE9_CRYNJ Unreviewed; 265 AA.
AC Q5KPE9; Q560E7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=ER to Golgi transport-related protein, putative {ECO:0000313|EMBL:AAW40907.1};
GN OrderedLocusNames=CNA03040 {ECO:0000313|EMBL:AAW40907.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW40907.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW40907.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RER1 family.
CC {ECO:0000256|ARBA:ARBA00006070}.
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DR EMBL; AE017341; AAW40907.1; -; Genomic_DNA.
DR RefSeq; XP_566726.1; XM_566726.1.
DR AlphaFoldDB; Q5KPE9; -.
DR STRING; 214684.Q5KPE9; -.
DR PaxDb; 214684-Q5KPE9; -.
DR EnsemblFungi; AAW40907; AAW40907; CNA03040.
DR GeneID; 3253415; -.
DR KEGG; cne:CNA03040; -.
DR VEuPathDB; FungiDB:CNA03040; -.
DR eggNOG; KOG1688; Eukaryota.
DR HOGENOM; CLU_074889_0_0_1; -.
DR InParanoid; Q5KPE9; -.
DR OMA; RFWYSIT; -.
DR OrthoDB; 415184at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR004932; Rer1.
DR PANTHER; PTHR10743; PROTEIN RER1; 1.
DR PANTHER; PTHR10743:SF0; PROTEIN RER1; 1.
DR Pfam; PF03248; Rer1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 29427 MW; 57A3845BA41DEF66 CRC64;
MNPQTYPAVN PYPPTQAAPS AGPGSGFPPK SGLAGMTPHS MSSTPVPNMA PGAGVRGGLP
EERNVAQLVR ENTNVWARKW QGLLDRSTPH VLERWLVTLG LFLLFALNVI LRQGWYIVCY
ALAIYILNLF LAFLQPRFDP SLAEDLAADD VEEGAPGLPG AGPAKTPGGL KGLLNGFSNG
EEDEEFRPFI RRLPEFKFWY SATKANAIAL LCTITRATDV PVYWPILLVY FFTLFGLTMR
RQIQHMIKYR YVPFDLGKKA RYGRK
//
