ID Q5L066_GEOKA Unreviewed; 556 AA.
AC Q5L066;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=GK1385 {ECO:0000313|EMBL:BAD75670.1};
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909 {ECO:0000313|EMBL:BAD75670.1, ECO:0000313|Proteomes:UP000001172};
RN [1] {ECO:0000313|EMBL:BAD75670.1, ECO:0000313|Proteomes:UP000001172}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426 {ECO:0000313|EMBL:BAD75670.1,
RC ECO:0000313|Proteomes:UP000001172};
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; BA000043; BAD75670.1; -; Genomic_DNA.
DR RefSeq; WP_011230882.1; NC_006510.1.
DR AlphaFoldDB; Q5L066; -.
DR STRING; 235909.GK1385; -.
DR KEGG; gka:GK1385; -.
DR PATRIC; fig|235909.7.peg.1496; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_026842_0_0_9; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001172}.
FT DOMAIN 35..336
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 56..63
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 556 AA; 65675 MW; A5A86A3EFF8C2D7C CRC64;
MQTTADLRKK RLDFARRSAR AWQNYFDAHG LLPNITLSPE QISVVQQDED QMLINGSAGT
GKSLTLIYKL LKVMEQENEP KRILYCSFNT MLVEDARKRI EQSSKFHEIK DKHTLHMETF
HYMAARILRE IGFPNAEFLR INLENLRRYE DAITRRTIAL VDTFMESEEY KELPLEQKLY
KTHAGTFLMD EILWMKANGF VTEESYYHCE RAGRGNIPRL TKEQRRTIFY LYKEYEKMLK
KQFHDHLDLE DYALLLLKYF DDIPDLLKYD YIFVDEVQDL QAMQLKALVG LAKKSIVVSG
DPKQRIYKRS PFSYRDLGLH IEGRKTRNLR TNYRSTKQIM KLASSLEFID AENDRLDDQR
FVREGKKPSI YFFPSSKELS CHLVNQVKVI QKNDPDATIA VIHRHDGDTY AISQCSVLME
LKKHFDVITS SQYGRRFDLN KQKKPILFTD AYSVKGLEFD YVFLIHFDRD HYPNKKRIEE
LDKRAGDNKN SDGYKADFEA ILNDEKKVLY VAITRAKKEV QLMYTGRNFR SICPFVRNFY
KEDYDAFGFD SSIYSK
//
