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Database: UniProt
Entry: Q5L3G9
LinkDB: Q5L3G9
Original site: Q5L3G9 
ID   CSHA_GEOKA              Reviewed;         467 AA.
AC   Q5L3G9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   16-OCT-2019, entry version 92.
DE   RecName: Full=DEAD-box ATP-dependent RNA helicase CshA {ECO:0000255|HAMAP-Rule:MF_01493};
DE            EC=3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_01493};
GN   Name=cshA {ECO:0000255|HAMAP-Rule:MF_01493}; OrderedLocusNames=GK0226;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of
RT   thermophilic Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: DEAD-box RNA helicase possibly involved in RNA
CC       degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-
CC       dependent ATPase activity. {ECO:0000255|HAMAP-Rule:MF_01493}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01493};
CC   -!- SUBUNIT: Oligomerizes, may be a member of the RNA degradosome.
CC       {ECO:0000255|HAMAP-Rule:MF_01493}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01493}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. CshA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01493}.
DR   EMBL; BA000043; BAD74511.1; -; Genomic_DNA.
DR   RefSeq; WP_011229736.1; NC_006510.1.
DR   SMR; Q5L3G9; -.
DR   STRING; 235909.GK0226; -.
DR   PRIDE; Q5L3G9; -.
DR   EnsemblBacteria; BAD74511; BAD74511; GK0226.
DR   KEGG; gka:GK0226; -.
DR   eggNOG; ENOG4105C1J; Bacteria.
DR   eggNOG; COG0513; LUCA.
DR   HOGENOM; HOG000268810; -.
DR   KO; K05592; -.
DR   OMA; RNPIRIL; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0043590; C:bacterial nucleoid; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0003724; F:RNA helicase activity; ISS:UniProtKB.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0010501; P:RNA secondary structure unwinding; IEA:InterPro.
DR   HAMAP; MF_01493; DEAD_helicase_CshA; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR030880; DEAD_helicase_CshA.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome; RNA-binding; Stress response.
FT   CHAIN         1    467       DEAD-box ATP-dependent RNA helicase CshA.
FT                                /FTId=PRO_0000280057.
FT   DOMAIN       33    203       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_01493}.
FT   DOMAIN      214    374       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_01493}.
FT   NP_BIND      46     53       ATP. {ECO:0000255|HAMAP-Rule:MF_01493}.
FT   MOTIF         2     30       Q motif.
FT   MOTIF       151    154       DEAD box.
SQ   SEQUENCE   467 AA;  52449 MW;  84EF44ADB0463C97 CRC64;
     MTTFQELGLS QEVMKAIERM GFEETTPIQA KTIPLSLQNK DVIGQAQTGT GKTAAFGIPI
     VEKVNVKNSA VQALVVAPTR ELAIQVSEEL YKIGAVKRVR VLPIYGGQDI ERQIRALKKH
     PHVIVGTPGR IIDHINRGTL RLEHVHTVVL DEADEMLNMG FIEDIEAILS HVPAERQTLL
     FSATMPDPIR RIAERFMNEP ELVKVKAKEM TVPNIQQYYL EVHEKKKFDI LTRLLDIQAP
     ELAIVFGRTK RRVDELAEAL NLRGYAAEGI HGDLSQAKRL SVLRKFKEGA IEILVATDVA
     ARGLDISGVT HVYNFDIPQD PESYVHRIGR TGRAGKTGVA MTFVTPREIG QLHHIERTTK
     RKMERMKPPT LDEALEGQQR IAIEKLLNVV ETENLSFYKR AAEELLEEHD SVTIVAACLK
     MLTREPDTTP VQLTEEPPLA VKREKKRGGR PDGSARSRTK KRRITAH
//
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