ID Q5M4B8_STRT2 Unreviewed; 283 AA.
AC Q5M4B8;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN OrderedLocusNames=stu1060 {ECO:0000313|EMBL:AAV60712.1};
OS Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=264199 {ECO:0000313|EMBL:AAV60712.1, ECO:0000313|Proteomes:UP000001170};
RN [1] {ECO:0000313|EMBL:AAV60712.1, ECO:0000313|Proteomes:UP000001170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-250 / LMG 18311 {ECO:0000313|Proteomes:UP000001170};
RX PubMed=15543133; DOI=10.1038/nbt1034;
RA Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT "Complete sequence and comparative genome analysis of the dairy bacterium
RT Streptococcus thermophilus.";
RL Nat. Biotechnol. 22:1554-1558(2004).
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DR EMBL; CP000023; AAV60712.1; -; Genomic_DNA.
DR RefSeq; WP_011226011.1; NC_006448.1.
DR AlphaFoldDB; Q5M4B8; -.
DR STRING; 264199.stu1060; -.
DR GeneID; 66898894; -.
DR KEGG; stl:stu1060; -.
DR PATRIC; fig|264199.4.peg.1045; -.
DR eggNOG; COG4667; Bacteria.
DR HOGENOM; CLU_048271_1_0_9; -.
DR Proteomes; UP000001170; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07208; Pat_hypo_Ecoli_yjju_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045943; DUF6363.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR037483; YjjU-like.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF25; PHOSPHOESTERASE-RELATED; 1.
DR Pfam; PF19890; DUF6363; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001170}.
FT DOMAIN 5..171
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 283 AA; 32406 MW; 0D4A1251148A7E3D CRC64;
MKVGLVLEGG GMRGLYTAGV LDAFLEAGIK VDGVVSVSAG ALFGVNYLSN QPKRALRYNK
RFMGDRRYMS FWSWLTTGNF VNKEFSYYKV PMELDVFDQD AFAESGVPFY VVATDIKTGK
PDYIKIDHVF EQMEALRASS ALPLVSEIVE YKGKRYMDGG LADSLPIDFM ESMGFDKLIV
VLTRPKGYRK HPSKTSKRFY KLFYRKYPEF VEVASNRHIH YNKSIEKIET LEKSGKVYAI
RPEHALEVGR LEKNPEKFEA IYQEGLKQMR NDMTNLKIFL GDN
//
