ID Q5M559_STRT2 Unreviewed; 387 AA.
AC Q5M559;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=Class I SAM-dependent rRNA methyltransferase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=stu0637 {ECO:0000313|EMBL:AAV60343.1};
OS Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=264199 {ECO:0000313|EMBL:AAV60343.1, ECO:0000313|Proteomes:UP000001170};
RN [1] {ECO:0000313|EMBL:AAV60343.1, ECO:0000313|Proteomes:UP000001170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-250 / LMG 18311 {ECO:0000313|Proteomes:UP000001170};
RX PubMed=15543133; DOI=10.1038/nbt1034;
RA Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT "Complete sequence and comparative genome analysis of the dairy bacterium
RT Streptococcus thermophilus.";
RL Nat. Biotechnol. 22:1554-1558(2004).
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DR EMBL; CP000023; AAV60343.1; -; Genomic_DNA.
DR RefSeq; WP_002950251.1; NC_006448.1.
DR AlphaFoldDB; Q5M559; -.
DR STRING; 264199.stu0637; -.
DR GeneID; 66898545; -.
DR KEGG; stl:stu0637; -.
DR eggNOG; COG1092; Bacteria.
DR HOGENOM; CLU_014042_1_2_9; -.
DR Proteomes; UP000001170; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11572; RlmI_M_like; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR Gene3D; 3.30.750.80; RNA methyltransferase domain (HRMD) like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR041532; RlmI-like_PUA.
DR InterPro; IPR019614; SAM-dep_methyl-trfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43042:SF3; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K; 1.
DR PANTHER; PTHR43042; SAM-DEPENDENT METHYLTRANSFERASE; 1.
DR Pfam; PF10672; Methyltrans_SAM; 1.
DR Pfam; PF17785; PUA_3; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001170};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..63
FT /note="RlmI-like PUA"
FT /evidence="ECO:0000259|Pfam:PF17785"
FT DOMAIN 161..347
FT /note="S-adenosylmethionine-dependent methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF10672"
SQ SEQUENCE 387 AA; 43647 MW; BA4B9EC8EF6F4AD6 CRC64;
MNILTVSPFA EKKIKQGKQL LLAEDFPNIA ENNQLVYLYS QSKEFLGTGY LSSQNKGIGW
FLSPKKQQLT VTYFQGLFEK AKARRQSYYA NDLTTAFRLF NQDGDDFGGL TIDLYGDYAL
FSWYNVFIYS LKDIIVEAFQ TVFPEVLGGY EKIRFKGLDF ESDHLYGQEA ADTFTILENG
VTYEVFLNDG LMTGIFLDQH EVRDGLVNGL ALGKSVLNMF SYTAAFSVAA AMGGAVETTS
VDLAKRSREL STAHFEANGF SMENHRLVVM DVFDYFKYAK KKGLFYDLIV IDPPSFARNK
KRTFSANKDY HKLIAQSLDI LSEYGTIIAS TNAANMTVQQ FKKQLRKGLG DVSADFVNLQ
QLPVDFAVNP NDPTSNYLKV YTIKVNK
//
