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Database: UniProt
Entry: Q5M6F5_STRT2
LinkDB: Q5M6F5_STRT2
Original site: Q5M6F5_STRT2 
ID   Q5M6F5_STRT2            Unreviewed;       133 AA.
AC   Q5M6F5;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Mini-ribonuclease 3 {ECO:0000256|HAMAP-Rule:MF_01468};
DE            Short=Mini-3 {ECO:0000256|HAMAP-Rule:MF_01468};
DE            Short=Mini-RNase 3 {ECO:0000256|HAMAP-Rule:MF_01468};
DE            EC=3.1.26.- {ECO:0000256|HAMAP-Rule:MF_01468};
DE   AltName: Full=Mini-RNase III {ECO:0000256|HAMAP-Rule:MF_01468};
DE            Short=Mini-III {ECO:0000256|HAMAP-Rule:MF_01468};
GN   Name=mrnC {ECO:0000256|HAMAP-Rule:MF_01468};
GN   OrderedLocusNames=stu0085 {ECO:0000313|EMBL:AAV59814.1};
OS   Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=264199 {ECO:0000313|EMBL:AAV59814.1, ECO:0000313|Proteomes:UP000001170};
RN   [1] {ECO:0000313|EMBL:AAV59814.1, ECO:0000313|Proteomes:UP000001170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-250 / LMG 18311 {ECO:0000313|Proteomes:UP000001170};
RX   PubMed=15543133; DOI=10.1038/nbt1034;
RA   Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA   Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D.,
RA   Fonstein M., Overbeek R., Kyprides N., Purnelle B., Prozzi D.,
RA   Ngui K., Masuy D., Hancy F., Burteau S., Boutry M., Delcour J.,
RA   Goffeau A., Hols P.;
RT   "Complete sequence and comparative genome analysis of the dairy
RT   bacterium Streptococcus thermophilus.";
RL   Nat. Biotechnol. 22:1554-1558(2004).
CC   -!- FUNCTION: Involved in correct processing of both the 5' and 3'
CC       ends of 23S rRNA precursor. Processes 30S rRNA precursor
CC       transcript even in absence of ribonuclease 3 (Rnc); Rnc processes
CC       30S rRNA into smaller rRNA precursors. {ECO:0000256|HAMAP-
CC       Rule:MF_01468}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01468};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01468}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01468}.
CC   -!- SIMILARITY: Belongs to the MrnC RNase family. {ECO:0000256|HAMAP-
CC       Rule:MF_01468}.
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DR   EMBL; CP000023; AAV59814.1; -; Genomic_DNA.
DR   RefSeq; WP_002948449.1; NC_006448.1.
DR   STRING; 264199.stu0085; -.
DR   EnsemblBacteria; AAV59814; AAV59814; stu0085.
DR   GeneID; 31939683; -.
DR   KEGG; stl:stu0085; -.
DR   eggNOG; ENOG4105KEB; Bacteria.
DR   eggNOG; COG1939; LUCA.
DR   HOGENOM; HOG000218681; -.
DR   KO; K11145; -.
DR   OMA; AIFEVYV; -.
DR   BioCyc; STHE264199:G1G41-113-MONOMER; -.
DR   Proteomes; UP000001170; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR   CDD; cd00593; RIBOc; 1.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   HAMAP; MF_01468; RNase_Mini_III; 1.
DR   InterPro; IPR008226; Mini3_fam.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   PIRSF; PIRSF005520; UCP005520; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001170};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01468};
KW   Endonuclease {ECO:0000256|HAMAP-Rule:MF_01468};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01468};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_01468};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_01468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001170};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_01468};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_01468};
KW   rRNA processing {ECO:0000256|HAMAP-Rule:MF_01468};
KW   rRNA-binding {ECO:0000256|HAMAP-Rule:MF_01468}.
FT   DOMAIN       15    112       RNase III. {ECO:0000259|Pfam:PF00636}.
FT   ACT_SITE     20     20       {ECO:0000256|HAMAP-Rule:MF_01468}.
SQ   SEQUENCE   133 AA;  15333 MW;  B9760AB891804DB7 CRC64;
     MTKHIDVNLI NGIALAFEGD AVYSLYIRRH LIFQGQTKPN QLHRLATCYV SAKAQASLIE
     KMLERELLTE KELDIYKRGR NAKSHTKAKN TDVITYKMST GFEAVMGYLH MTEDIDRLEE
     LVAWCIDEVE KEI
//
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