ID Q5NCB7_MOUSE Unreviewed; 510 AA.
AC Q5NCB7;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 2.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=Trim7 {ECO:0000313|Ensembl:ENSMUSP00000039011.6,
GN ECO:0000313|MGI:MGI:2137353};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000039011.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000039011.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000039011.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000039011.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000039011.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; NP_001334375.1; NM_001347446.1.
DR AlphaFoldDB; Q5NCB7; -.
DR SMR; Q5NCB7; -.
DR ProteomicsDB; 352906; -.
DR Antibodypedia; 29710; 174 antibodies from 27 providers.
DR DNASU; 94089; -.
DR Ensembl; ENSMUST00000046903.6; ENSMUSP00000039011.6; ENSMUSG00000040350.17.
DR GeneID; 94089; -.
DR AGR; MGI:2137353; -.
DR CTD; 81786; -.
DR MGI; MGI:2137353; Trim7.
DR VEuPathDB; HostDB:ENSMUSG00000040350; -.
DR GeneTree; ENSGT01030000234669; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR OMA; DMKMHIC; -.
DR PhylomeDB; Q5NCB7; -.
DR BioGRID-ORCS; 94089; 3 hits in 62 CRISPR screens.
DR ChiTaRS; Trim7; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000040350; Expressed in right kidney and 125 other cell types or tissues.
DR ExpressionAtlas; Q5NCB7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR CDD; cd19762; Bbox2_TRIM7-like; 1.
DR CDD; cd16594; RING-HC_TRIM7-like_C-IV; 1.
DR CDD; cd13740; SPRY_PRY_TRIM7; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR020457; Znf_B-box_chordata.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF689; E3 UBIQUITIN-PROTEIN LIGASE TRIM7; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01406; BBOXZNFINGER.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|ProteomicsDB:Q5NCB7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 29..81
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 124..165
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 323..510
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 165..214
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 510 AA; 56993 MW; B761110ABC12DC3F CRC64;
MATVGPRTGP NAGAEALALA AELQGEATCS ICLEFFREPV SVECGHSFCR ACIMRCWERP
GAGTGTATRT LPCPLPCPQC REPARPSQLR PNRQLAAVAS LLRRFSLPPT APGERGTPAV
PARAAAARCS QHGEQLKLYC QDDGRAICVV CDRAREHRSH AVLPLEEAVQ EAKELLDSRL
RALKKVLEDY EAFRSTEERE SKELLKQMAA EKEKVGAEFQ ALRAFLVEQE GRLLSRLEVL
SREVTQKQNE NLAQLEGEIT QLSKLSGQIQ ETAQKPDLDF LQEFKSTLSK CSSVPSSKPT
TVSSEMKNKV WNVSLKSFVL KGLLKKFKED LQGELEKEEK VELTLDPDTA NPRLILSLDL
KSVRLGQRAQ DLPNHPRRFD TNTRVLASCG FSSGRHHWEV EVGSKDGWAF GVARESVRRK
GLTPFTPEEG VWAMQLNNGQ YWAVTSPERT QLNCGHLSRV RVALDLEVGA VSFYAVEDMR
HLYTFRVNFQ ERVFPLFSVC STGTYLRIWP
//
