ID Q5NCJ4_MOUSE Unreviewed; 1123 AA.
AC Q5NCJ4;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE SubName: Full=Rap guanine nucleotide exchange factor (GEF) 6 {ECO:0000313|Ensembl:ENSMUSP00000092114.4};
GN Name=Rapgef6 {ECO:0000313|Ensembl:ENSMUSP00000092114.4,
GN ECO:0000313|MGI:MGI:2384761};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000092114.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000092114.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092114.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000092114.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092114.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR AlphaFoldDB; Q5NCJ4; -.
DR SMR; Q5NCJ4; -.
DR jPOST; Q5NCJ4; -.
DR MaxQB; Q5NCJ4; -.
DR PeptideAtlas; Q5NCJ4; -.
DR ProteomicsDB; 363754; -.
DR Ensembl; ENSMUST00000094536.10; ENSMUSP00000092114.4; ENSMUSG00000037533.21.
DR AGR; MGI:2384761; -.
DR MGI; MGI:2384761; Rapgef6.
DR VEuPathDB; HostDB:ENSMUSG00000037533; -.
DR GeneTree; ENSGT00940000158124; -.
DR ChiTaRS; Rapgef6; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000037533; Expressed in lymph node and 242 other cell types or tissues.
DR ExpressionAtlas; Q5NCJ4; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0030139; C:endocytic vesicle; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0030742; F:GTP-dependent protein binding; ISO:MGI.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:MGI.
DR GO; GO:0070300; F:phosphatidic acid binding; ISO:MGI.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR GO; GO:0030033; P:microvillus assembly; ISO:MGI.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:Q5NCJ4,
KW ECO:0007829|MaxQB:Q5NCJ4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..95
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 127..241
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 245..315
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 464..550
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 575..803
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 355..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 127096 MW; F855C89809BFBC49 CRC64;
MSVRRELCSV MVFEVVEQAG AVILEDGQEL DSWYVILNGT VEISHPDGKI ENLFMGNSFG
IVPTLDKQHM HGAVRTKVDD CQFVCIAQQD YWRILNHVEK NTHKVEEEGE IVMVHEHREL
DRSGTRKGHI VIKATPERLI MHLIEEHSIV DPTYIEDFLL TYRTFLETPL DVGIKLLEWF
KIDNLRDKVT RIVLLWVNNH FNDFEGDPAM TQFLEEFERN LEDTKMNGHL RLLNIACAAK
AKWRQVVLQK ASRESPLHFC LTGGSEKGFG VFVEEVESGS KAADAGLKRG DQVMEVNGQN
FENITLAKAL EILRNNTHLA LTVKTNIFVF KELLSRTEQE KSGVPHIPKI AEKKSNRHSI
QDVPGDMEQA PQEKGNKKIK ANTVSGGRNK IRKILDKTRF SILPPKLFSD GGLSQSQDDS
IVGTRHCRHS LAIMPIPGTL SSSSPDLLQP TTSMLDFSNP SDIPDQVIRV FKADQQSCYI
IISKDTTAKE VVCQAVQEFG LTGASDTYSL CEVSVTPEGV IKQRRLPDQF SKLADRIQLN
GRYYLKNNME TETLCSDEDA QELLKESQLS MLQLSTIEVA TQLSMRDFDL FRNIEPTEYI
DDLFKLDSKT GNTHLKQFED IVNQETFWVA SEILSESNQL KRMKIIKHFI KIALHCRECK
NFNSMFAIIS GLNLAPVARL RGTWEKLPSK YEKHLQDLQD LFDPSRNMAK YRNILSSQSM
QPPIIPLFPV VKKDMTFLHE GNDSKVDGLV NFEKLRMIAK EIRHIIRMTS ANMDPAMMFR
QRSLSQGSTN SNMLDVQGGA HKKRARRSSL LNAKKLYEDA QMARKVKQYL SSLDIDTDEE
KFQMMSLQWE PAYGTLTKNL TEKRSAKSSE MSPVPLRSVG QTAKVHLHQP HRVSQVLQVP
AVNLHPIRKK GQAKDHVLST SLPQKGLGPT EEVSVKKHTE DTISVASSLH SSPPASPQNS
PRKVGSILSD HSILLRLSGS SSSPPREPST KISGQSCPGI GGVYLQKKIL QITGSTAKRT
DRTKKATEEN RDRTRCEDTT RRRMTSPFRR FRERTLSRER LVNNQKEDAH HNQATDSCEK
VKDVGSNITD ERGNAIYDSS SQGHSTALSC FCTRFKTKRR KTL
//