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Database: UniProt
Entry: Q5NH93_FRATT
LinkDB: Q5NH93_FRATT
Original site: Q5NH93_FRATT 
ID   Q5NH93_FRATT            Unreviewed;       280 AA.
AC   Q5NH93; A0A0G2RM75;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   08-MAY-2019, entry version 79.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254,
GN   ECO:0000313|EMBL:CAG45208.1};
GN   OrderedLocusNames=FTT_0575 {ECO:0000313|EMBL:CAG45208.1};
OS   Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=177416 {ECO:0000313|EMBL:CAG45208.1, ECO:0000313|Proteomes:UP000001174};
RN   [1] {ECO:0000313|EMBL:CAG45208.1, ECO:0000313|Proteomes:UP000001174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCHU S4 / Schu 4 {ECO:0000313|Proteomes:UP000001174};
RX   PubMed=15640799; DOI=10.1038/ng1499;
RA   Larsson P., Oyston P.C.F., Chain P., Chu M., Duffield M.,
RA   Fuxelius H.H., Garcia E., Halltorp G., Johansson D., Isherwood K.,
RA   Karp P., Larsson E., Lui Y., Michell S., Prior J., Prior R.,
RA   Sjostedt A., Svensson K., Thompson N., Vergez L., Wagg J., Wren B.,
RA   Lindler L.E., Andersson S.G., Forsman M., Titball R.W.;
RT   "The complete genome sequence of Francisella tularensis, the causative
RT   agent of tularemia.";
RL   Nat. Genet. 37:153-159(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; AJ749949; CAG45208.1; -; Genomic_DNA.
DR   RefSeq; WP_003023296.1; NZ_CP010290.1.
DR   RefSeq; YP_169599.1; NC_006570.2.
DR   DNASU; 3191368; -.
DR   EnsemblBacteria; AJI69047; AJI69047; BZ14_251.
DR   EnsemblBacteria; CAG45208; CAG45208; FTT_0575.
DR   GeneID; 3191368; -.
DR   KEGG; ftu:FTT_0575; -.
DR   PATRIC; fig|177416.36.peg.255; -.
DR   eggNOG; ENOG4105CQC; Bacteria.
DR   eggNOG; COG0077; LUCA.
DR   HOGENOM; HOG000018970; -.
DR   KO; K04518; -.
DR   OMA; HTRFVIL; -.
DR   BioCyc; FTUL177416:G1G1C-662-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000001174; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001174};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:CAG45208.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001174}.
SQ   SEQUENCE   280 AA;  31841 MW;  7FA17B4EEC735E13 CRC64;
     MIKVSFQGEH GAYSEQAITN FLEQQNIKDF QTVTCWSFSD AIEHTISGKS NFVMIPVENS
     LAGSVVPAYD ELIKSNLKVK AEVVLKIKHC LMGLNDVEIS EIESVISHPQ ALSQCANSLK
     KLKLTPEAFV DTAGAAKYIF EKNKRNHLAI AGELAAKTYR LKIFQHELED EQFNYTRFLL
     MGYDDIKVNS ADNKYKTTII FSVEDKSNAL VNTLNVFSKY NINLTKIESR PSRNRAWNYL
     FFIDFEGSDD DFNVQQALLE VLKKSTFLKV LGSYKSYHFS
//
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