ID Q5NHJ4_FRATT Unreviewed; 303 AA.
AC Q5NHJ4; A0A0G2RN19;
DT 01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=DNA polymerase III subunit delta' {ECO:0000256|ARBA:ARBA00014363};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=holB {ECO:0000313|EMBL:CAG45093.1};
GN OrderedLocusNames=FTT_0460 {ECO:0000313|EMBL:CAG45093.1};
OS Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=177416 {ECO:0000313|EMBL:CAG45093.1, ECO:0000313|Proteomes:UP000001174};
RN [1] {ECO:0000313|EMBL:CAG45093.1, ECO:0000313|Proteomes:UP000001174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCHU S4 / Schu 4 {ECO:0000313|Proteomes:UP000001174};
RX PubMed=15640799; DOI=10.1038/ng1499;
RA Larsson P., Oyston P.C.F., Chain P., Chu M., Duffield M., Fuxelius H.H.,
RA Garcia E., Halltorp G., Johansson D., Isherwood K., Karp P., Larsson E.,
RA Lui Y., Michell S., Prior J., Prior R., Sjostedt A., Svensson K.,
RA Thompson N., Vergez L., Wagg J., Wren B., Lindler L.E., Andersson S.G.,
RA Forsman M., Titball R.W.;
RT "The complete genome sequence of Francisella tularensis, the causative
RT agent of tularemia.";
RL Nat. Genet. 37:153-159(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; AJ749949; CAG45093.1; -; Genomic_DNA.
DR RefSeq; WP_003020243.1; NZ_CP010290.1.
DR RefSeq; YP_169498.1; NC_006570.2.
DR AlphaFoldDB; Q5NHJ4; -.
DR DNASU; 3192338; -.
DR EnsemblBacteria; CAG45093; CAG45093; FTT_0460.
DR KEGG; ftu:FTT_0460; -.
DR PATRIC; fig|177416.36.peg.393; -.
DR OrthoDB; 9811073at2; -.
DR Proteomes; UP000001174; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR015199; DNA_pol_III_delta_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11669:SF8; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF09115; DNApol3-delta_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CAG45093.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001174};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAG45093.1}.
FT DOMAIN 191..301
FT /note="DNA polymerase III delta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09115"
SQ SEQUENCE 303 AA; 35297 MW; C7BA15B932355244 CRC64;
MLSLTTHQQL IDNFLEQKAK QTLRHAFIFR VEDAVLLDSF INSLCQLLLG EKILSYDDSP
YINIAAIEND EIKVAEIKKI IKNCELTAHN NLAKIIIIQG LDLLNESAAN ALLKTLEEPT
QNTFFLMFTR NYSDVLATVK SRSLVYDIKF TQKDKYNYLS YTFDMSKDAI EKSLQMTRND
INIIAKIKLE QHFWQLRNNL MKVLANQVNL NVFLKEVNPH FKDTLYWLTS MIIDVYCYKL
DEQNQGIANY DKLAIIKYLA AKFDADCIYK LYSKALEAQS YFVKFKNVDK ELILENLILE
IIK
//
