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Database: UniProt
Entry: Q5R5M1
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ID   PRDM4_PONAB             Reviewed;         801 AA.
AC   Q5R5M1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   13-FEB-2019, entry version 102.
DE   RecName: Full=PR domain zinc finger protein 4;
DE            EC=2.1.1.-;
DE   AltName: Full=PR domain-containing protein 4;
GN   Name=PRDM4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcription factor involved in cell
CC       differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; CR860836; CAH92945.1; -; mRNA.
DR   RefSeq; NP_001126735.1; NM_001133263.1.
DR   RefSeq; XP_009246470.1; XM_009248195.1.
DR   UniGene; Pab.8113; -.
DR   ProteinModelPortal; Q5R5M1; -.
DR   SMR; Q5R5M1; -.
DR   STRING; 9601.ENSPPYP00000005606; -.
DR   Ensembl; ENSPPYT00000005821; ENSPPYP00000005606; ENSPPYG00000004913.
DR   GeneID; 100173737; -.
DR   KEGG; pon:100173737; -.
DR   CTD; 11108; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; KOG2461; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00940000156443; -.
DR   HOGENOM; HOG000060213; -.
DR   HOVERGEN; HBG053672; -.
DR   InParanoid; Q5R5M1; -.
DR   KO; K12463; -.
DR   OMA; NGVLEFC; -.
DR   OrthoDB; 1318335at2759; -.
DR   TreeFam; TF332513; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1990226; F:histone methyltransferase binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR017124; PRDM4.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   PIRSF; PIRSF037161; PRDM4; 1.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Methyltransferase;
KW   Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    801       PR domain zinc finger protein 4.
FT                                /FTId=PRO_0000341944.
FT   DOMAIN      412    529       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     545    566       C2H2-type 1; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   ZN_FING     618    640       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     646    668       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     674    696       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     702    724       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     730    752       C2H2-type 6; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   COMPBIAS     93     98       Poly-Pro.
FT   COMPBIAS    757    760       Poly-Ser.
FT   COMPBIAS    763    767       Poly-Glu.
SQ   SEQUENCE   801 AA;  87874 MW;  DB52DEC6531A6955 CRC64;
     MHHRMNEMNL SPVGMEQLTS SSVSNALPVS GSHLGLAASP THSAIPAPGL PVAIPNLGPS
     LSSLPSALSL MLPMGIGDRG VMCGLPERNY TLPPPPYPHL ESSYFRTILP GILSYLADRP
     PPQYIHPNSI NVDGNTALSI TNNASALDPY QSNGNVGLEP GIVSIDSRSV NTHGAQSLHP
     SDGHEVALDT AITMENVSRV TSPISTDGMA EELTMDGVAG EHSQIPNGSR SHEPLSVDSV
     SNNLAADAVG HGGVIPMHGN GLELPVVMET DHIASRVNGM SDSALSDSIH TVAMSTNSVS
     VALSTSHNLA SLESVSLHEV GLSLEPVAVS SITQEVAMGT GHVDVSSDSL SFVPPSLQME
     DSNSNKENMA TLFTIWCTLC DRAYPSDCPE HGPVTFVPDT PIESRARLSL PKQLVLRQSI
     VGAEVGVWTG ETIPVRTCFG PLIGQQSHSM EVAEWTDKAV NHIWKIYHNG VLEFCIITAD
     ENECNWMMFV RKARNREEQN LVAYPHDGKI FFCTSQDIPP ENELLFYYSR DYAQQIGVPE
     HPDVHLCNCG KECNSYTEFK AHLTSHIHNH LPTQGHSGSH GPSHSKERKW KCSMCPQAFI
     SPSKLHVHFM GHMGMKPHKC DFCSKAFSDP SNLRTHLKIH TGQKNYRCTL CDKSFTQKAH
     LESHMVIHTG EKNLKCDYCD KLFMRRQDLK QHVLIHTQER QIKCPKCDKL FLRTNHLKKH
     LNSHEGKRDY VCEKCTKAYL TKYHLTRHLK TCKGPTSSSS APEEEEEDDS EEEDLADSVG
     TEDCRINSAV YSADESLSAH K
//
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