ID Q5RCB3_PONAB Unreviewed; 328 AA.
AC Q5RCB3;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=DNA repair protein {ECO:0000256|PIRNR:PIRNR005856};
GN Name=DKFZp459M168 {ECO:0000313|EMBL:CAH90594.1};
GN Synonyms=RAD51D {ECO:0000313|Ensembl:ENSPPYP00000009193.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:CAH90594.1};
RN [1] {ECO:0000313|EMBL:CAH90594.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cortex {ECO:0000313|EMBL:CAH90594.1};
RG The German cDNA Consortium;
RA Koehrer K., Beyer A., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G.,
RA Han M., Wiemann S.;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000009193.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000009193.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA breaks arising during DNA replication or induced
CC by DNA-damaging agents. {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
CC {ECO:0000256|PIRNR:PIRNR005856}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR858364; CAH90594.1; -; mRNA.
DR RefSeq; NP_001125321.1; NM_001131849.1.
DR RefSeq; XP_009249776.1; XM_009251501.1.
DR Ensembl; ENSPPYT00000009564.2; ENSPPYP00000009193.1; ENSPPYG00000008178.3.
DR GeneID; 100172220; -.
DR KEGG; pon:100172220; -.
DR CTD; 5892; -.
DR eggNOG; KOG1433; Eukaryota.
DR GeneTree; ENSGT00940000159095; -.
DR HOGENOM; CLU_058452_0_0_1; -.
DR OMA; QRIHTFR; -.
DR OrthoDB; 11612at2759; -.
DR TreeFam; TF101219; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd19489; Rad51D; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047323; Rad51D_C.
DR InterPro; IPR048943; RAD51D_N.
DR InterPro; IPR020588; RecA_ATP-bd.
DR PANTHER; PTHR46457; DNA REPAIR PROTEIN RAD51 HOMOLOG 4; 1.
DR PANTHER; PTHR46457:SF1; DNA REPAIR PROTEIN RAD51 HOMOLOG 4; 1.
DR Pfam; PF08423; Rad51; 1.
DR Pfam; PF21794; RAD51D_N; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005856};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 78..251
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
SQ SEQUENCE 328 AA; 35154 MW; 64D875F8D7C865C1 CRC64;
MGVLRVGLCP GLTQEMIQLL RSRRIKTVVD LVSADLEELA QKCGLSYKAL VALRRVLLAQ
FSAFPVNGAD LYEELKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCV
AANVAHGLQQ NVLYVDSNGG LTASRLLQLL QAKTQDEEEQ AEALQRIQVV HAFDIFQMLD
VLQELRGTVA QQVTGSSGTV RVVVVDSVTA VVSPLLGGQQ REGLALMMQL ARELKTLARD
LGMAVVVTNH TTRDRDSRRL KPALGRSWSF VPSTRILLDT IEGAGASGGR RMACLTKSSR
QPTGFQEMVD TGTWGTSEQS ATLQGDQT
//
