ID   CEP76_PONAB             Reviewed;         658 AA.
AC   Q5RCP7;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=Centrosomal protein of 76 kDa;
DE            Short=Cep76;
GN   Name=CEP76;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Centrosomal protein involved in regulation of centriole
CC       duplication. Required to limit centriole duplication to once per cell
CC       cycle by preventing centriole reduplication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CCP110 and CEP97. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole {ECO:0000250}. Note=Does not
CC       localize along the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}.
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DR   EMBL; CR858222; CAH90460.1; -; mRNA.
DR   RefSeq; NP_001125237.1; NM_001131765.1.
DR   AlphaFoldDB; Q5RCP7; -.
DR   SMR; Q5RCP7; -.
DR   STRING; 9601.ENSPPYP00000010081; -.
DR   GeneID; 100172131; -.
DR   KEGG; pon:100172131; -.
DR   CTD; 79959; -.
DR   eggNOG; ENOG502QQEI; Eukaryota.
DR   InParanoid; Q5RCP7; -.
DR   OrthoDB; 315381at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   Gene3D; 3.10.620.30; -; 1.
DR   InterPro; IPR028926; CEP76-C2.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR46436; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR   PANTHER; PTHR46436:SF1; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR   Pfam; PF15627; CEP76-C2; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..658
FT                   /note="Centrosomal protein of 76 kDa"
FT                   /id="PRO_0000089502"
FT   MOD_RES         74
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q0VEJ0"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TAP6"
SQ   SEQUENCE   658 AA;  74317 MW;  D746E197B346B95F CRC64;
     MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQHLSTED LIKALRRRGI
     IDDVMKELNF VTDSVERELP SSPKQPICFD RQSTLKKTNI DPTRRYLYLQ VLGGKAFLEH
     LQEPEPLPGQ VCSTFTLCLH YRNQRFRSKP VPCACEPDFH DGFLLEVHRE SLGDGTRMAD
     STTMLSISDP IHMVLIKTDI FGETTLVASY FLEWRSVLGS ENGVTSLTVE LMGVGTESKV
     SVGILNIKLE MYPPLNQTLS QEVVNTQLAL ERQKTAEKER LFLVYAKQWW REYLQIRPSH
     NSRLVKIFAQ DENGVNRPVC SYVKPLRAGR LLDTPRQAAR FVNVLGYERA PVIGGGGKQE
     QWCTLLAFLC RNKGDCEDHA NLLCSLLLGY GLEAFVCVGT KAKGVPHAWV MTCGTDGTTT
     FWESLTGHRY IHKPTNPDEP PVAEQPKPLY PYRTIGCVFN HQMFLGNCQP SDAVETCVFD
     LNDESKWKPM SEEAIKSVCA PGATTSLPPF PPLCASTIDA SVTSNEIEMQ LRLLVSEHRK
     DLGLTTVWED QLSYLLSPAL ASYEFERTTS ISAGNEEFQD AIRRAVPDGH TFKGFPIHFV
     YRNARRAFAT CLRSPFCEEI ICCRGDQVRL AVRVRVFTYP ESACAVWIMF ACKYRSVL
//