GenomeNet

Database: UniProt
Entry: Q5RDP6
LinkDB: Q5RDP6
Original site: Q5RDP6 
ID   MGP_PONAB               Reviewed;         103 AA.
AC   Q5RDP6;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   RecName: Full=Matrix Gla protein;
DE            Short=MGP;
DE   Flags: Precursor;
GN   Name=MGP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with the organic matrix of bone and
CC       cartilage. Thought to act as an inhibitor of bone formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its
CC       function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
DR   EMBL; CR857858; CAH90111.1; -; mRNA.
DR   RefSeq; NP_001125014.1; NM_001131542.1.
DR   PRIDE; Q5RDP6; -.
DR   GeneID; 100171893; -.
DR   KEGG; pon:100171893; -.
DR   CTD; 4256; -.
DR   InParanoid; Q5RDP6; -.
DR   KO; K19481; -.
DR   OrthoDB; 1512503at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR027118; MGP.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   PANTHER; PTHR10109; PTHR10109; 1.
DR   PRINTS; PR00002; GLABONE.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis; Complete proteome; Developmental protein;
KW   Differentiation; Disulfide bond; Gamma-carboxyglutamic acid;
KW   Osteogenesis; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     19       {ECO:0000250}.
FT   CHAIN        20     96       Matrix Gla protein.
FT                                /FTId=PRO_0000011113.
FT   PROPEP       97    103       Removed in mature form; probably by
FT                                carboxypeptidase N.
FT                                /FTId=PRO_0000011114.
FT   DOMAIN       51     97       Gla. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   MOD_RES      21     21       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      22     22       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P07507}.
FT   MOD_RES      25     25       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P07507}.
FT   MOD_RES      28     28       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P07507}.
FT   MOD_RES      56     56       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      60     60       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      67     67       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      71     71       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   DISULFID     73     79       {ECO:0000255|PROSITE-ProRule:PRU00463}.
SQ   SEQUENCE   103 AA;  12322 MW;  D457FB7C967843CA CRC64;
     MKSLVLLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NIFISPQQRW RAKVQERIRE
     RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRERR GAK
//
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