ID ASB11_PONAB Reviewed; 323 AA.
AC Q5RFS1;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE RecName: Full=Ankyrin repeat and SOCS box protein 11;
DE Short=ASB-11;
GN Name=ASB11;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; CR857081; CAH89386.1; -; mRNA.
DR RefSeq; NP_001124584.1; NM_001131112.1.
DR AlphaFoldDB; Q5RFS1; -.
DR SMR; Q5RFS1; -.
DR STRING; 9601.ENSPPYP00000022531; -.
DR Ensembl; ENSPPYT00000023489.2; ENSPPYP00000022531.1; ENSPPYG00000020141.2.
DR GeneID; 100171419; -.
DR KEGG; pon:100171419; -.
DR CTD; 140456; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160592; -.
DR HOGENOM; CLU_000134_4_1_1; -.
DR InParanoid; Q5RFS1; -.
DR OrthoDB; 50291at2759; -.
DR TreeFam; TF331945; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001595; Chromosome X.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03728; SOCS_ASB_9_11; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037333; ASB9/11_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24136:SF14; ANKYRIN REPEAT AND SOCS BOX PROTEIN 11; 1.
DR PANTHER; PTHR24136; SOWAH (DROSOPHILA) HOMOLOG; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..323
FT /note="Ankyrin repeat and SOCS box protein 11"
FT /id="PRO_0000066946"
FT REPEAT 64..93
FT /note="ANK 1"
FT REPEAT 97..126
FT /note="ANK 2"
FT REPEAT 130..159
FT /note="ANK 3"
FT REPEAT 162..191
FT /note="ANK 4"
FT REPEAT 195..224
FT /note="ANK 5"
FT REPEAT 227..256
FT /note="ANK 6"
FT DOMAIN 274..323
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ SEQUENCE 323 AA; 35348 MW; 7BD85C75FCBAF322 CRC64;
MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS
DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN
GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQFE VHLASPIHEA VKRGHRECME
ILLANNVNID HEVPQLGTPL YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN
VEVIHLLTDY GANLKRRNAQ GKSALDLAAP KSSVEQALLL CEGPPALSQL CRLCVRKCLG
RACHQAIHKL HLPEPLERFL LYQ
//
