ID Q5RH13_DANRE Unreviewed; 400 AA.
AC Q5RH13; B3DI53;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE SubName: Full=F-box and leucine-rich repeat protein 14b {ECO:0000313|EMBL:AAI63001.1, ECO:0000313|Ensembl:ENSDARP00000067321};
GN Name=fbxl14b {ECO:0000313|Ensembl:ENSDARP00000067321,
GN ECO:0000313|RefSeq:NP_001015043.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-3556};
GN Synonyms=fbxl14 {ECO:0000313|EMBL:AAI63001.1,
GN ECO:0000313|RefSeq:NP_001015043.1}, ppab
GN {ECO:0000313|RefSeq:NP_001015043.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63001.1};
RN [1] {ECO:0000313|RefSeq:NP_001015043.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11976951; DOI=10.1007/s00427-002-0222-7;
RA Das T., Purkayastha-Mukherjee C., D'Angelo J., Weir M.;
RT "A conserved F-box gene with unusual transcript localization.";
RL Dev. Genes Evol. 212:134-140(2002).
RN [2] {ECO:0000313|EMBL:AAI63001.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001015043.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19439512;
RA Kassahn K.S., Dang V.T., Wilkins S.J., Perkins A.C., Ragan M.A.;
RT "Evolution of gene function and regulatory control after whole-genome
RT duplication: comparative analyses in vertebrates.";
RL Genome Res. 19:1404-1418(2009).
RN [4] {ECO:0000313|RefSeq:NP_001015043.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21793410;
RA Zheng H., Li S., Wu Z., Zhang Y., Hu S., Yan Y., Li Y.;
RT "Differential response of multiple zebrafish hepatic F-box protein genes to
RT 17alpha-ethinylestradiol treatment.";
RL J. Environ. Sci. 23:664-670(2011).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000067321, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067321};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000067321}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000067321};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_001015043.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_001015043.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX649324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163001; AAI63001.1; -; mRNA.
DR EMBL; BC163002; AAI63002.1; -; mRNA.
DR RefSeq; NP_001015043.1; NM_001015043.2.
DR STRING; 7955.ENSDARP00000067321; -.
DR PaxDb; 7955-ENSDARP00000067321; -.
DR Ensembl; ENSDART00000067322; ENSDARP00000067321; ENSDARG00000045801.
DR Ensembl; ENSDART00000067322.5; ENSDARP00000067321.3; ENSDARG00000045801.7.
DR GeneID; 324835; -.
DR KEGG; dre:324835; -.
DR AGR; ZFIN:ZDB-GENE-030131-3556; -.
DR CTD; 324835; -.
DR ZFIN; ZDB-GENE-030131-3556; fbxl14b.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_016072_7_0_1; -.
DR OMA; DQALVHI; -.
DR OrthoDB; 940118at2759; -.
DR TreeFam; TF313434; -.
DR Reactome; R-DRE-8951664; Neddylation.
DR Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000000437; Chromosome 4.
DR Bgee; ENSDARG00000045801; Expressed in gastrula and 28 other cell types or tissues.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IPI:ZFIN.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IC:ZFIN.
DR GO; GO:0016567; P:protein ubiquitination; IC:ZFIN.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd22125; F-box_FBXL14; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR047932; FBXL14_F-box.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR13318:SF190; JETLAG, ISOFORM A; 1.
DR PANTHER; PTHR13318; UNCHARACTERIZED; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF13516; LRR_6; 6.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 11.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 2..48
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
SQ SEQUENCE 400 AA; 44448 MW; D8E37E005F700422 CRC64;
METHISCLFP EILAMIFSYL DVRDKGRVAQ VCTAWRDASY HKSVWRGVEA KLHLRRANPS
LFPSLQARGI RRVQILSLRR SLSYVIQGMP NIESLNLSGC YNLTDNGLGH AFVQEIPSLR
VLNLSLCKQI TDSSLGRIAQ YLKNLEVLEL GGCSNITNTG LLLIAWGLHR LKSLNLRSCR
HVSDVGIGHL AGMTRSAAEG CLSLEYLTLQ DCQKLTDLSL KHISKGLTKL KVLNLSFCGG
ISDAGMIHLS HMTSLWSLNL RSCDNISDTG IMHLAMGTLR LSGLDVSFCD KIGDQSLAYI
AQGLYQLKSL SLCSCHISDD GINRMVRQMH ELRTLNIGQC VRITDKGLEL IADHLTQLTG
IDLYGCTKIT KRGLERITQL PCLKVLNLGL WQMTESEKVR
//
