ID Q5RHT9_DANRE Unreviewed; 580 AA.
AC Q5RHT9; A0A8M9PH78;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE SubName: Full=Neuroepithelial cell-transforming 1 {ECO:0000313|Ensembl:ENSDARP00000011006};
DE SubName: Full=Neuroepithelial cell-transforming gene 1 protein isoform X2 {ECO:0000313|RefSeq:XP_021330687.1};
GN Name=net1 {ECO:0000313|Ensembl:ENSDARP00000011006,
GN ECO:0000313|RefSeq:XP_021330687.1,
GN ECO:0000313|ZFIN:ZDB-GENE-041121-18};
GN Synonyms=wu:fb13g03 {ECO:0000313|RefSeq:XP_021330687.1}, wu:fb25c11
GN {ECO:0000313|RefSeq:XP_021330687.1}, zgc:92121
GN {ECO:0000313|RefSeq:XP_021330687.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000011006};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000011006, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000011006};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000011006}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000011006};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_021330687.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021330687.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; BX465862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_021330687.1; XM_021475012.1.
DR PaxDb; 7955-ENSDARP00000011006; -.
DR Ensembl; ENSDART00000002682; ENSDARP00000011006; ENSDARG00000032765.
DR Ensembl; ENSDART00000002682.8; ENSDARP00000011006.6; ENSDARG00000032765.7.
DR AGR; ZFIN:ZDB-GENE-041121-18; -.
DR ZFIN; ZDB-GENE-041121-18; net1.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_027428_2_0_1; -.
DR OMA; ECGENDP; -.
DR PhylomeDB; Q5RHT9; -.
DR TreeFam; TF328974; -.
DR Reactome; R-DRE-193648; NRAGE signals death through JNK.
DR Reactome; R-DRE-416482; G alpha (12/13) signalling events.
DR Reactome; R-DRE-8980692; RHOA GTPase cycle.
DR Reactome; R-DRE-9013026; RHOB GTPase cycle.
DR Proteomes; UP000000437; Chromosome 4.
DR Bgee; ENSDARG00000032765; Expressed in tail bud paraxial mesoderm and 30 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:ZFIN.
DR GO; GO:0019887; F:protein kinase regulator activity; TAS:ZFIN.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:ZFIN.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:ZFIN.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0048382; P:mesendoderm development; IMP:ZFIN.
DR GO; GO:0038092; P:nodal signaling pathway; IDA:ZFIN.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR GO; GO:1900107; P:regulation of nodal signaling pathway; IMP:ZFIN.
DR GO; GO:0044332; P:Wnt signaling pathway involved in dorsal/ventral axis specification; IMP:ZFIN.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF4; NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 148..330
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 360..475
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 97..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 65505 MW; 9AEDF3B074C8D4E9 CRC64;
MMQCHRRQSY TRLGVWPSLR RGSSFTFLTP GPQWDFTLKR KRREKDDADA VSLCSFDFKE
PCTKRVRPLG RVTSLANLIS PVKNGAVRRF GQTLQASFRG DGRSPGVPQQ KPCSKAAAPT
PPKRRNSTLW SETLDVHQKG TFSTKEIKRQ EAIFELSRGE QDLIEDLKLA RKAYHDPMLK
LSIMSEEELT AIFGDLDAYI PLHEDLLDQL AKATGTDGTV RQIGKIVVDW LPRLNAYRAY
CSNQLAAKAL LDQKKQDPRV QDFLQRCLES PFSRKLDLWS FLDIPRSRLV KYPLLLKEIL
RHTPPDHPDK GSLEQAISVI QAVLADINMK KGESECQYYI DKLEYLEDKQ KDPRIEQCKS
LLCHGELRNK SGTKLHVFLF TEVLILTRPV TRNDRHCFQV YRQPIPVQDL VLEDLQDGDV
RMGGSFRGAF SNADKAKNIF RVRFQDASQG QSHTLQVNDV FHKQQWLNCL RNAMSTQKDL
TLSENEPLTT PATDVCAKRR SSSVSTVIQM DEMDENCPRA AASAPSSPSS EEPPSPTPSA
TSTLSSSSSS SSISAPIPSR KSKKDKRSLC PLGKRKETMV
//
