ID Q5RJQ2_RAT Unreviewed; 466 AA.
AC Q5RJQ2;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE SubName: Full=Male-specific lethal 3-like 1 (Drosophila) {ECO:0000313|EMBL:AAH86548.1};
DE SubName: Full=Male-specific lethal-3 homolog 1 (Drosophila) {ECO:0000313|EMBL:EDL90575.1};
GN Name=Msl3 {ECO:0000313|RGD:1549763};
GN Synonyms=Msl31 {ECO:0000313|EMBL:EDL90575.1}, Msl3l1
GN {ECO:0000313|EMBL:AAH86548.1};
GN ORFNames=rCG_49705 {ECO:0000313|EMBL:EDL90575.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH86548.1};
RN [1] {ECO:0000313|EMBL:AAH86548.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000313|EMBL:AAH86548.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000313|EMBL:EDL90575.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDL90575.1};
RX PubMed=15632090; DOI=10.1101/gr.2889405;
RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA Istrail S., Li P., Sutton G.;
RT "Gene and alternative splicing annotation with AIR.";
RL Genome Res. 15:54-66(2005).
RN [3] {ECO:0000313|EMBL:EDL90575.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDL90575.1};
RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F.,
RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G.,
RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BC086548; AAH86548.1; -; mRNA.
DR EMBL; CH474014; EDL90575.1; -; Genomic_DNA.
DR RefSeq; NP_001014133.1; NM_001014111.1.
DR SMR; Q5RJQ2; -.
DR STRING; 10116.ENSRNOP00000061187; -.
DR PhosphoSitePlus; Q5RJQ2; -.
DR PaxDb; 10116-ENSRNOP00000061187; -.
DR GeneID; 317464; -.
DR KEGG; rno:317464; -.
DR AGR; RGD:1549763; -.
DR CTD; 10943; -.
DR RGD; 1549763; Msl3.
DR VEuPathDB; HostDB:ENSRNOG00000004016; -.
DR eggNOG; KOG3001; Eukaryota.
DR HOGENOM; CLU_039566_5_2_1; -.
DR OrthoDB; 2878816at2759; -.
DR Reactome; R-RNO-3214847; HATs acetylate histones.
DR Proteomes; UP000234681; Chromosome x.
DR Bgee; ENSRNOG00000004016; Expressed in quadriceps femoris and 20 other cell types or tissues.
DR GO; GO:0072487; C:MSL complex; ISO:RGD.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0046972; F:histone H4K16 acetyltransferase activity; ISO:RGD.
DR GO; GO:0035064; F:methylated histone binding; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:RGD.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; ISO:RGD.
DR Gene3D; 1.10.274.30; MRG domain; 2.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR008676; MRG.
DR InterPro; IPR038217; MRG_C_sf.
DR InterPro; IPR026541; MRG_dom.
DR PANTHER; PTHR10880:SF47; MALE-SPECIFIC LETHAL 3 HOMOLOG; 1.
DR PANTHER; PTHR10880; MORTALITY FACTOR 4-LIKE PROTEIN; 1.
DR Pfam; PF05712; MRG; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51640; MRG; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 107..450
FT /note="MRG"
FT /evidence="ECO:0000259|Pfam:PF05712"
FT REGION 61..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 53531 MW; F7DBE6E054B6E2B1 CRC64;
MPSWDRWAAE DHVLHDTDEN RRLQRKLAKK AIARLRGTGK KKRRCRLPGV DSVLKSVPVK
EKTKNDENSI SSTCHESCGE KNGGIKEHRQ RRIKVKTKGK KKVLSLRSRK DMDERTITIE
IPEVLKKQLE DDCYYINRRK RLVKLPCQTN IITILESYVK HFAINAAFSA NERPRHHHAM
MHAHMNVHYV PAEKNVDLCK EMVDGLRITF DYTLPLVLLY PYEQTQYKRV TSSKFFLPIK
ESTTTTNRSQ EELSPSPPLL NPSTPQSTES QPPTGEPATP KRRKAEPEAL QSLRRSTRHS
TNCDRLSESS SSPQPKRRQQ DTSTSMPKLF LHLEKKTPVH SRSSSPIPLT PSKDGSAVFA
GFEGRRTNEI NEVLSWKLVP DNYPPGDQPP PPSYIYGAQH LLRLFVKLPE ILGKMSFSEK
NLKALLKHFD LFLRFLAEYH DDFFPESAYV AACEAHYSTK NPRAIY
//
