ID Q5RKI5_RAT Unreviewed; 1270 AA.
AC Q5RKI5;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE SubName: Full=Flightless I homolog (Drosophila) {ECO:0000313|EMBL:AAH85829.1};
GN Name=Flii {ECO:0000313|RGD:1307590};
GN Synonyms=Fliih {ECO:0000313|EMBL:AAH85829.1};
GN ORFNames=rCG_32758 {ECO:0000313|EMBL:EDM04657.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH85829.1};
RN [1] {ECO:0000313|EMBL:AAH85829.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000313|EMBL:AAH85829.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000313|EMBL:EDM04657.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDM04657.1};
RX PubMed=15632090; DOI=10.1101/gr.2889405;
RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA Istrail S., Li P., Sutton G.;
RT "Gene and alternative splicing annotation with AIR.";
RL Genome Res. 15:54-66(2005).
RN [3] {ECO:0000313|EMBL:EDM04657.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BN {ECO:0000313|EMBL:EDM04657.1};
RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F.,
RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G.,
RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC085829; AAH85829.1; -; mRNA.
DR EMBL; CH473948; EDM04657.1; -; Genomic_DNA.
DR RefSeq; NP_001008280.1; NM_001008279.1.
DR SMR; Q5RKI5; -.
DR IntAct; Q5RKI5; 1.
DR STRING; 10116.ENSRNOP00000006753; -.
DR PhosphoSitePlus; Q5RKI5; -.
DR PaxDb; 10116-ENSRNOP00000006753; -.
DR GeneID; 287375; -.
DR KEGG; rno:287375; -.
DR UCSC; RGD:1307590; rat.
DR AGR; RGD:1307590; -.
DR CTD; 2314; -.
DR RGD; 1307590; Flii.
DR VEuPathDB; HostDB:ENSRNOG00000004159; -.
DR eggNOG; KOG0444; Eukaryota.
DR HOGENOM; CLU_002568_1_0_1; -.
DR OrthoDB; 25995at2759; -.
DR TreeFam; TF313468; -.
DR Proteomes; UP000234681; Chromosome 10.
DR Bgee; ENSRNOG00000004159; Expressed in skeletal muscle tissue and 19 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005903; C:brush border; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; ISO:RGD.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR GO; GO:0008154; P:actin polymerization or depolymerization; IBA:GO_Central.
DR GO; GO:0051016; P:barbed-end actin filament capping; IBA:GO_Central.
DR GO; GO:0030239; P:myofibril assembly; IBA:GO_Central.
DR CDD; cd11280; gelsolin_like; 2.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.20.10; Severin; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF139; PROTEIN FLIGHTLESS-1 HOMOLOG; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 5.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00597; GELSOLIN.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 9.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 5.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 509..591
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 629..703
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 759..831
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 1076..1144
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 1182..1255
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 448..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 144857 MW; A5421FFC95F5FE64 CRC64;
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE ELAALQKLEH
LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI FKLDDLSVLD LSHNQLTECP
RELENAKNML VLNLSHNSID SIPNQLFINL TDLLYLDLSE NRLESLPPQM RRLVHLQTLV
LNGNPLLHAQ LRQLPAMMAL QTLHLRNTQR TQSNLPTSLE GLSNLSDVDL SCNDLTRVPE
CLYTLPNLHR LNLSSNQIAE LSLCIDQWVH LETLNLSRNQ LTSLPSAICK LTKLKKLYLN
SNKLDFDGLP SGIGKLTSLE EFMAANNNLE LIPESLCRCP KLRKLVLNKN RLVTLPEAIH
FLTEIEVLDV RENPSLVMPP KPADHTAEWY NIDFSLQNQL RLAGASPATV AAAAAVGSGS
KDPLARKMRL RRRKDSAQDV QAKQVLKGMS DVAQEKNKNQ EESTDARAPG GKVRRWDQGL
EKPRLDYSEF FTEDVGQLPG LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS
LNWEIYYWIG GEATLDKKAC SAIHAVNLRN YLGAECRTAR EEMGDESEGF LQVFDNDISY
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL DQGLDIYVWR
GAQATLSNTT KARLFAEKMN KNERKGKAEI TLLVQGQEPP EFWDVLGGEP SEIKKHVPDD
FWPPQPKLYK VGLGLGYLEL PQINYKLSVE HKKRPKVELM PGMRLLQSLL DTRCVYILDC
WSDVFIWLGR KSPRLVRAAA LKLGQELCGM LHRPRHTVVS RSLEGTEAQV FKAKFKNWDD
VLTVDYTRNA EAVLQGPGIS GKVKRDTEKK DQMKADLTAL FLPRQPPMPL AEAEQLMEEW
NEDLDGMEGF VLEGRKFTRL AEEEFGHFYT QDCYVFLCRY WVPVEYEEEE KPEDKEGKAS
AEGREEEEAA AETEEKQPEE DFQCIVYFWQ GREASNMGWL TFTFSLQKKF ESLFPGKLEV
VRMTQQQENP KFLSHFKRKF IIHRGKRKVT QTLQPTLYQI RTNGSALCTR CIQINTDSSL
LNSEFCFILK VPFESEDNQG IVYAWVGRAS DPDEAKLAED ILNTMFDPSY SKQVINEGEE
PENFFWVGIG AQKPYDDDAE YMKHTRLFRC SNEKGYFAVT EKCSDFCQDD LADDDIMLLD
NGQEVYMWVG TQTSQVEIKL SLKACQVYIQ HTRSKEHERP RRLRLVRKGN EQRAFTRCFH
AWSTFRQAPA
//
