ID Q5SIW4_THET8 Unreviewed; 627 AA.
AC Q5SIW4;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN OrderedLocusNames=TTHA1250 {ECO:0000313|EMBL:BAD71073.1};
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852 {ECO:0000313|EMBL:BAD71073.1, ECO:0000313|Proteomes:UP000000532};
RN [1] {ECO:0000313|EMBL:BAD71073.1, ECO:0000313|Proteomes:UP000000532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8 {ECO:0000313|Proteomes:UP000000532};
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AP008226; BAD71073.1; -; Genomic_DNA.
DR RefSeq; WP_011228547.1; NC_006461.1.
DR RefSeq; YP_144516.1; NC_006461.1.
DR AlphaFoldDB; Q5SIW4; -.
DR SMR; Q5SIW4; -.
DR EnsemblBacteria; BAD71073; BAD71073; BAD71073.
DR GeneID; 3168437; -.
DR KEGG; ttj:TTHA1250; -.
DR PATRIC; fig|300852.9.peg.1229; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_6_0; -.
DR PhylomeDB; Q5SIW4; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000532}.
FT DOMAIN 28..81
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 83..472
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 527..604
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 627 AA; 69845 MW; 299D53FFFE5D84EA CRC64;
MALEKLLKVQ ERLWAPEDLR KKANLQDYAA EYRKSLEDPE GFWGAWARRF HWEKPFEKVL
EWTLPEHRWF LGGTTNAVYN ALERNVERGL RNKVALLYLA EDGREEKLTY GELLDRVRRL
ATGLRRLGVG KGDRVVIYMP LTLEGVLAML ATAYIGAIHS VVYAGLGVSA LRERILDAQA
KLLIAGDVSF RRGKGVDLRS IAEEAIRDLP LKVVWFQRAY KAELAEGHYD FHELLWGNPP
EARAEMVDAE HPLFILYTSG STGKPKGVVH VHGGYMVGTT YHLRTFFDVK DEDVFWATSD
IGWIVGHSYI VYAPLLEGIT SVLREGAPDH PDPGALWQAV ERYRVNVMFT APTAVRMFMK
YGPEWPRKYD LSSLRLLAVA GEPLNPEALK WAYEHLVDGG RRGFVADNWW QTELGGPTLG
TPLVLPAKPG FAGVALPGVE AEVVDEEGRP VPPGQGGLLV LKRPFPHMMR TVWGNHERYL
RYWQEVPGGV YASGDVASKD EEGYFSVLGR ADDVLNVAGH RIGTADVESA LVSHPAVAEA
AVIGVPDPLK GEAIKAFVVL RLGQTPSEEL KEALVQHVRR ELGPIATPSE VVFLDKLPKT
RSGKILRRLL KAQALGKDPG DLSTLEE
//
