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Database: UniProt
Entry: Q5SVY0_MOUSE
LinkDB: Q5SVY0_MOUSE
Original site: Q5SVY0_MOUSE 
ID   Q5SVY0_MOUSE            Unreviewed;       123 AA.
AC   Q5SVY0;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   05-DEC-2018, entry version 88.
DE   SubName: Full=2-oxoglutarate dehydrogenase, mitochondrial {ECO:0000313|Ensembl:ENSMUSP00000117323};
DE   Flags: Fragment;
GN   Name=Ogdh {ECO:0000313|Ensembl:ENSMUSP00000117323,
GN   ECO:0000313|MGI:MGI:1098267};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117323, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000117323, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117323,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000117323}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117323};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:23806337}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z.,
RA   Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
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DR   EMBL; AL607152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MaxQB; Q5SVY0; -.
DR   PeptideAtlas; Q5SVY0; -.
DR   PRIDE; Q5SVY0; -.
DR   Ensembl; ENSMUST00000140765; ENSMUSP00000117323; ENSMUSG00000020456.
DR   MGI; MGI:1098267; Ogdh.
DR   eggNOG; KOG0450; Eukaryota.
DR   eggNOG; COG0567; LUCA.
DR   GeneTree; ENSGT00940000153913; -.
DR   HOGENOM; HOG000259586; -.
DR   HOVERGEN; HBG094366; -.
DR   OMA; IDMVCYR; -.
DR   ChiTaRS; Ogdh; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000020456; Expressed in 326 organ(s), highest expression level in heart.
DR   ExpressionAtlas; Q5SVY0; baseline and differential.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Proteomics identification {ECO:0000213|EPD:Q5SVY0,
KW   ECO:0000213|MaxQB:Q5SVY0, ECO:0000213|PeptideAtlas:Q5SVY0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN       48     86       2-oxogl_dehyd_N. {ECO:0000259|Pfam:
FT                                PF16078}.
FT   NON_TER     123    123       {ECO:0000313|Ensembl:ENSMUSP00000117323}.
SQ   SEQUENCE   123 AA;  13581 MW;  F734C5EC9E9ABD94 CRC64;
     MFHLRTCAAK LRPLTASQTV KTFSQNKPAA IRTFQQIRCY SAPVAAEPFL SGTSSNYVEE
     MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RSSLATMAHA QSLVEAQPNV
     DKL
//
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