ID Q5SZT6_MOUSE Unreviewed; 480 AA.
AC Q5SZT6;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 159.
DE SubName: Full=Zinc finger with KRAB and SCAN domains 4 {ECO:0000313|Ensembl:ENSMUSP00000054604.6};
GN Name=Zkscan4 {ECO:0000313|Ensembl:ENSMUSP00000054604.6,
GN ECO:0000313|MGI:MGI:3649412};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000054604.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000054604.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000054604.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000054604.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000054604.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR RefSeq; NP_001034204.1; NM_001039115.2.
DR AlphaFoldDB; Q5SZT6; -.
DR SMR; Q5SZT6; -.
DR STRING; 10090.ENSMUSP00000054604; -.
DR iPTMnet; Q5SZT6; -.
DR PhosphoSitePlus; Q5SZT6; -.
DR MaxQB; Q5SZT6; -.
DR PaxDb; 10090-ENSMUSP00000054604; -.
DR PeptideAtlas; Q5SZT6; -.
DR ProteomicsDB; 331254; -.
DR Ensembl; ENSMUST00000062609.6; ENSMUSP00000054604.6; ENSMUSG00000054931.10.
DR GeneID; 544922; -.
DR KEGG; mmu:544922; -.
DR UCSC; uc007pqn.2; mouse.
DR AGR; MGI:3649412; -.
DR MGI; MGI:3649412; Zkscan4.
DR VEuPathDB; HostDB:ENSMUSG00000054931; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159644; -.
DR HOGENOM; CLU_002678_49_4_1; -.
DR InParanoid; Q5SZT6; -.
DR OMA; KESQWEN; -.
DR OrthoDB; 5255661at2759; -.
DR PhylomeDB; Q5SZT6; -.
DR TreeFam; TF350830; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 544922; 1 hit in 79 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q5SZT6; Protein.
DR Bgee; ENSMUSG00000054931; Expressed in cortical plate and 102 other cell types or tissues.
DR ExpressionAtlas; Q5SZT6; baseline and differential.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14196; ODD-SKIPPED - RELATED; 1.
DR PANTHER; PTHR14196:SF11; ZINC FINGER PROTEIN 208-LIKE; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Proteomics identification {ECO:0007829|ProteomicsDB:Q5SZT6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 51..133
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 253..280
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 281..308
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 309..336
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 337..364
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 365..392
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 420..447
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 448..475
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 389..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 54069 MW; F7F2084A58EC4E53 CRC64;
MAREPGTSAA LNARSAEEGT GLLVVKVEQE EASPLAEETS WLGSPGPDRS RQRFRAFRYP
EAAGPRQALS RLRELCRQWL RPDMHSKEQI LELLVLEQFL TILPGELQTW VREQHPDSGE
EVVALLEYLD RQLDDTPPQV STGEWSRELL CCKVAVVTPS QDSQSSHCQA MKSLFKHESQ
ESLECSPLQA RGLEMKPETR DLPRAEEYRD QKPEQTVCFL GEDTVPIPTG AEASEQEGKL
QTAQKSATGT RRHFCCECGK SFAQSSGLTK HKRIHTGEKP YECEDCGKTF IGSSALVIHQ
RVHTGEKPYE CEECGKVFSH SSNLIKHQRT HTGEKPYECD DCGKTFTQSC SLLEHHKIHT
GEKPFQCNLC GKAFRRSSHL LRHQRIHGDK TAPKPLHGEA WEGQSPVAGQ GEDVEAPETY
QCSECERSFT RRRSLLEHKK IHTGEKPYQC DACGKGFTRT SYLAQHQRSH VGKKLSHSDL
//
