ID Q5T5H8_HUMAN Unreviewed; 84 AA.
AC Q5T5H8;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Estrogen receptor 1 {ECO:0000313|Ensembl:ENSP00000385373.1};
DE Flags: Fragment;
GN Name=ESR1 {ECO:0000313|Ensembl:ENSP00000385373.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385373.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000385373.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000385373.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL035695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF454881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5T5H8; -.
DR SMR; Q5T5H8; -.
DR MassIVE; Q5T5H8; -.
DR PeptideAtlas; Q5T5H8; -.
DR ProteomicsDB; 64522; -.
DR Antibodypedia; 739; 4927 antibodies from 55 providers.
DR Ensembl; ENST00000404742.5; ENSP00000385373.1; ENSG00000091831.25.
DR UCSC; uc063shi.1; human.
DR HGNC; HGNC:3467; ESR1.
DR VEuPathDB; HostDB:ENSG00000091831; -.
DR GeneTree; ENSGT00940000158133; -.
DR HOGENOM; CLU_185688_0_0_1; -.
DR OMA; QCDARDE; -.
DR ChiTaRS; ESR1; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000091831; Expressed in oviduct epithelium and 160 other cell types or tissues.
DR ExpressionAtlas; Q5T5H8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR001292; Estr_rcpt.
DR InterPro; IPR046944; Estr_rcpt_N.
DR Pfam; PF02159; Oest_recep; 1.
DR PRINTS; PR00543; OESTROGENR.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5T5H8,
KW ECO:0007829|ProteomicsDB:Q5T5H8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 42..84
FT /note="Estrogen receptor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02159"
FT NON_TER 84
FT /evidence="ECO:0000313|Ensembl:ENSP00000385373.1"
SQ SEQUENCE 84 AA; 9033 MW; B1FB1A8BFDC55BC4 CRC64;
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY
EFNAAAAANA QVYGQTGLPY GPGS
//
