ID Q5TF45_HUMAN Unreviewed; 163 AA.
AC Q5TF45;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Mitochondrial translation release factor 1 like {ECO:0000313|Ensembl:ENSP00000415113.1};
DE Flags: Fragment;
GN Name=MTRF1L {ECO:0000313|Ensembl:ENSP00000415113.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415113.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000415113.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000415113.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835}.
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DR EMBL; AL080276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5TF45; -.
DR SMR; Q5TF45; -.
DR MassIVE; Q5TF45; -.
DR PeptideAtlas; Q5TF45; -.
DR ProteomicsDB; 65072; -.
DR Antibodypedia; 33386; 280 antibodies from 15 providers.
DR Ensembl; ENST00000448966.1; ENSP00000415113.1; ENSG00000112031.16.
DR UCSC; uc063sjo.1; human.
DR HGNC; HGNC:21051; MTRF1L.
DR VEuPathDB; HostDB:ENSG00000112031; -.
DR GeneTree; ENSGT00940000155683; -.
DR HOGENOM; CLU_1630848_0_0_1; -.
DR ChiTaRS; MTRF1L; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000112031; Expressed in left ventricle myocardium and 195 other cell types or tissues.
DR ExpressionAtlas; Q5TF45; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR Gene3D; 3.30.160.20; -; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF3; PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q5TF45,
KW ECO:0007829|MaxQB:Q5TF45};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 109..125
FT /note="Prokaryotic-type class I peptide chain release
FT factors"
FT /evidence="ECO:0000259|PROSITE:PS00745"
FT NON_TER 163
FT /evidence="ECO:0000313|Ensembl:ENSP00000415113.1"
SQ SEQUENCE 163 AA; 18251 MW; 07816C44CC8F2F2F CRC64;
MFISFYDFKN IPQDSRCDGQ LFINGRNNKN NSISLYFQGG LRHASASIGG SEAYRHMKFE
GGVHRVQRVP KTEKQGRVHT STMTVAILPQ PTEINLVINP KDLRIDTKRA SGAGGQHVNT
TDSAVRIVHL PTGVVSECQQ ERSQLKNKEL AMTKLRAKLY SMH
//
