ID Q5TQW5_ANOGA Unreviewed; 491 AA.
AC Q5TQW5;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 3.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=AGAP006483-PA {ECO:0000313|EMBL:EAL40098.3};
GN Name=SPZ2 {ECO:0000313|EMBL:EAL40098.3};
GN ORFNames=AgaP_AGAP006483 {ECO:0000313|EMBL:EAL40098.3};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAL40098.3};
RN [1] {ECO:0000313|EMBL:EAL40098.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAL40098.3};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAL40098.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL40098.3};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAL40098.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL40098.3};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAL40098.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL40098.3};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAL40098.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL40098.3};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL40098.3}.
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DR EMBL; AAAB01008960; EAL40098.3; -; Genomic_DNA.
DR RefSeq; XP_557166.3; XM_557166.4.
DR AlphaFoldDB; Q5TQW5; -.
DR STRING; 7165.Q5TQW5; -.
DR PaxDb; 7165-AGAP006483-PA; -.
DR GeneID; 3290180; -.
DR KEGG; aga:AgaP_AGAP006483; -.
DR CTD; 3290180; -.
DR VEuPathDB; VectorBase:AGAP029552; -.
DR eggNOG; ENOG502RZ0W; Eukaryota.
DR HOGENOM; CLU_042097_0_0_1; -.
DR InParanoid; Q5TQW5; -.
DR OMA; GPHFTND; -.
DR OrthoDB; 3686826at2759; -.
DR PhylomeDB; Q5TQW5; -.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005121; F:Toll binding; IBA:GO_Central.
DR GO; GO:0021556; P:central nervous system formation; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR032104; Spaetzle.
DR PANTHER; PTHR23199:SF12; NEUROTROPHIN 1-RELATED; 1.
DR PANTHER; PTHR23199; UNCHARACTERIZED; 1.
DR Pfam; PF16077; Spaetzle; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
PE 4: Predicted;
FT DOMAIN 56..146
FT /note="Spaetzle"
FT /evidence="ECO:0000259|Pfam:PF16077"
FT REGION 370..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 55539 MW; 3DD0F1C14C8B6DB8 CRC64;
MYSITRHRHA IGALLAEYID KANAQDRTVY EPDEIAQGIN TKLRKREDDP SKSGGSMCPS
IIRYARPQKA RSATGEWKYI VNTGEHTQTL RLEKCSTPQD SCTYLTDNFR SRCVQIYNYH
RLLSWDAARG LHVDIFKVPT CCSCHIDGYR ETFPPLTSYN SDFKSKIHED PSESASTLIR
NTHSNHHQQH HHSHYSTLQF DQVDEEEPED NIAYQFSNGF QRIKPKYEGA LHLPAVPPPQ
PPPPQGPVGA GLGKTRFERP PKHPAISKPK HPHFIAPPTL DTYLSPPPND LAYGIPFKRG
PHYTNENTLK RAGNVAGPNR RPLRKTATVQ HHADQSIAET DSRLNQVAVL PPGKMDLLPQ
TQAQNIIEKH RRRQQTTAQP PLTTLQQQQQ QQQQTHIFRI SQPSTPSMAV NPTVPLSTQP
QPPSTAGTST TTVTSTNGHQ RINYNYHPII DFFEEEEVPD VTQEQIDRIG LNSHSSLNSW
KPVITGRPRF H
//
