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Database: UniProt
Entry: Q5TQX0_ANOGA
LinkDB: Q5TQX0_ANOGA
Original site: Q5TQX0_ANOGA 
ID   Q5TQX0_ANOGA            Unreviewed;      2830 AA.
AC   Q5TQX0;
DT   07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 3.
DT   16-JAN-2019, entry version 111.
DE   SubName: Full=AGAP006475-PA {ECO:0000313|EMBL:EAL40093.3};
DE   SubName: Full=Inositol 1,4,5-triphosphate receptor type 1 {ECO:0000313|VectorBase:AGAP006475-PA};
GN   Name=1277082 {ECO:0000313|VectorBase:AGAP006475-PA};
GN   ORFNames=AgaP_AGAP006475 {ECO:0000313|EMBL:EAL40093.3};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAL40093.3, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAL40093.3, ECO:0000313|Proteomes:UP000007062, ECO:0000313|VectorBase:AGAP006475-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40093.3,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAL40093.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40093.3};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAL40093.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40093.3};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAL40093.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40093.3};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [5] {ECO:0000313|EMBL:EAL40093.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40093.3};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|VectorBase:AGAP006475-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP006475-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; AAAB01008960; EAL40093.3; -; Genomic_DNA.
DR   RefSeq; XP_557157.3; XM_557157.3.
DR   ProteinModelPortal; Q5TQX0; -.
DR   STRING; 7165.AGAP006475-PA; -.
DR   EnsemblMetazoa; AGAP006475-RA; AGAP006475-PA; AGAP006475.
DR   GeneID; 1277082; -.
DR   KEGG; aga:AgaP_AGAP006475; -.
DR   VectorBase; AGAP006475-RA; AGAP006475-PA; AGAP006475.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   HOGENOM; HOG000007660; -.
DR   InParanoid; Q5TQX0; -.
DR   KO; K04958; -.
DR   OMA; PRHAPYK; -.
DR   OrthoDB; 94996at2759; -.
DR   PhylomeDB; Q5TQX0; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2339   2368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2380   2400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2426   2449       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2469   2494       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2514   2536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2651   2674       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      176    228       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      236    292       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      299    365       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      371    427       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2789   2816       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2830 AA;  319591 MW;  1ED78B3D0C7C4554 CRC64;
     MGDSTIGSVS FLHLGDIVSL YSEGSVSGFL STLGLVDDRV VVCPGAGDLN EPPEKFRDCL
     IKICPMNRYS AQKQFWKAAK QSTTTNTDTS LLKRLHHAAE IEKKQNESEN KKLLGTVVQY
     GSVVQLLHLK SNKYVTVNIR LPALLEKNAM RVYLDANGNE GSWFYIMPFY KLRSAGDNVV
     VSDKVILKPV NANRQNLHVA VTYELPDNPG SKEVNVLNSS TSWKITLFME QRENQEDVLK
     GGDVVRLFHA EQEKFLTMDE YKKQQHVFLR TTGRSSATAA TSSKALWEVE VVQHDSCRGG
     AGHWNSLFRF KHLATGYYLA AEIDEDISRT EKSSSSSHPQ GGDSFRLVPV PHSSDIASVF
     ELDSTTITRP EGLVPQSSYV RLRHLCSSTW VHATSVPIDI DDDKPVMSKV GCSAIKEDKE
     AFQLIPVSPV EVRDLDFAND ACKLLLAMST KLENGTISSN ERRSLIALLQ DIVFFIAGQE
     NDQNKSDALD LTINNPNRDR QKLLREQYIL KQLFKILQGP FQETKNNDGP FLKIDELGDP
     KNAPFKNIFR LCYRILKLSQ QDYRKNQEYI AKHFGLMQKQ IGYDILAEDT ITALLHNNRK
     LLEKHITAAE IETFVGLVRK NMQSWQSRFL DYLSDLCVSN KKAIAVTQEL ICKSVLSSKN
     ADILIETFLR EVDDDPLGYL SELERGNREF TEIREVDEST SGVEGDSKGT TNGKRKLDEK
     KRYEVVLMWT NRTQSKSMSR LAQGLKIGRA VDTAILDYYR HQLNLFSNMC LNRQYLALNN
     LSPHLDIDLI LRCMSDKTVP YDLRASFCRL MLHLHVDRDP QEPVTPVKYA RLWSEIPTVM
     SINDYDIEKQ LDSNKEAVRA RFNKTIAFVE DYLCNHVVSK MWFADQDQNK LTFEVVKLAR
     DLIYFGFYSF SDLLRLTKTL LNILDCVSSS EADGTGLPTG HIDCNIPEAN IGAEGGVLRR
     IGDMGAVMTS LTLGPISTAI VSPTIQHRKS VSQLMKEYPL VMDTKLKIIE ILQFILDVRL
     DYRISCLLSI FKREFDENEQ TASTGAALAP PTVIVPETPT IIPPGGGGVP STTSDATSPA
     VSVVNINLRQ KNIDLESIGY QAEGIFGCTE DTYNPLDLDG QGGRTFLRVL LHLIMHEYPA
     LVSGALHLLF RHFSQRHEVL HAFRQVQLLV SDSDVESYKQ IKSDLDVLRQ SVEKSELWVY
     KSKQTDDLLA GGGGEESQLN FDQGPELNPE QSQEYKKIQQ ILIRMNKLCI TATGPDGFVK
     PRKHEQRLLR NVGVHTVVLD LLQIPYDEKD DYRMNELMRL AHEFLQNFCL GNQQNQILLH
     KQLDLFLNPG ILEAETVCAI FKDNLNLCNE VSDKVVQHFV HCIEIHGRHV EYLKFLQTII
     KAENQFIRKC QDMVMQELVN AGEEVLVFYN DKGSFNYFVE LMRSYSAGTL ADPSPLMYHI
     ELVKLLACCT MGKNVYTEIK CNSLLALDDI VAMISHPDCI PEVKVAYVDF LCHCYIDTEV
     EVKEIYSSNH MWCLFEKSFL IDINNVVKGG SFTNKQLENY VCNEVMNILT TFFNSQFSDQ
     STALQKRQLI FVKILQNSFK LTQCKGLTPS QRFNVENCIR TLSEKAKPRG IAIPIDLENQ
     VVKMFNKTAM LSRQTSKWLL VTKQTKMERS QSQIMRMDRS IIEGLQDIVS LLEDKLKPLV
     EAEQSLLVDI LYRSELLFPL NTESRKKCET GDFIRHLIKH TEKLLEEKEE KLCVKILKTL
     KEMMTIDCDY GDKGDHLRTI LLKRYFGNDF TLQAPVAALP GAVGPAVLQP ANVSTAVGSP
     MASVSHGPGA KYLIRAGRTL HEVQNHLDKE GASDLVIELV IKSINSPSIF VEAIELGIAL
     LEGGNPIIQK GMYNKFLSND LSQSFFKVFF DKMKDAQQEI KSTVTVNTSD MAANKASESK
     VEGKDLDKIG QRKNVNKVNG IVITEDFKEE LQNAALMTQQ SYINARNLAA ASDGTGSDNG
     DENSLMSIGS SALEDILAEK LEKHKDKDEN NKLSNKVLVM QPILRFLQLL CENHNPELQN
     LLRNQNNKTN YNLVSETLMF LDCICGSTTG GLGLLGLYIN ENNVSLINQT LETLTEYCQG
     PCHDNQNCIA THESNGLDII TALILNDINP LGKNRMDLVL ELKNNASKLL LAIMESRGDS
     ENAERILANM NPKQLVEVAC RAYHQDENIL MLLNQSDGGL RHDLGDDGHD DDDVGVSPKE
     VGHNIYILCH QLAQHNKELA GLLKIDTYNG SANSKTNQAL LYYQTHTAQI EIVRHDRTLE
     QIVFPIPEIC EYLTKDTKVR VLNTAERDDQ GSKVADFFDR HEAMFNEMKW QKKLRGQPAL
     FWVSSYMSLW SNILFNLAVL INLIVAFFYP FENALPELSF HLSSLIWIVM LVSLAIVITL
     PRQSGIRTFV VALILRLIFS CGPEPTLWLL GCITVIMKGV HIISLMGNYG TLEKHFVSII
     TDAELLYHFF YLLFCVFGVL LHPFFFSILL FDVVYREETL LNVIRSVTRN GRSIILTAVL
     ALILVYMFSI IGYMFFRDDF LVPVDEEYTP PAIPTAGDAG CTGDSATVSH MVPPDVVDQV
     VQATCSKPPG TASTELADDG GEMKERGCDS MIMCIITTLN QGLRNGGGIG DILRAPSRKE
     TLFVPRVVYD LLFFFIVIII VLNLIFGVII DTFADLRSEK QQKELILKNT CFICGLNRSA
     FDNKTVSFEE HIKNEHNMWH YLYFIVLVKV KDPTEFTGPE SYVHAMVKAN IQDWFPRLRA
     MSLAAVDGDG EQIELRSLKN LLETNHIAVR ELMTQIMELE NKMTEQRKQR QRHALLNPTT
     STSYQFYPQL
//
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