ID Q5TX35_ANOGA Unreviewed; 880 AA.
AC Q5TX35;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 2.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=AGAP007646-PA {ECO:0000313|EMBL:EAL41731.2};
GN ORFNames=AgaP_AGAP007646 {ECO:0000313|EMBL:EAL41731.2};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAL41731.2};
RN [1] {ECO:0000313|EMBL:EAL41731.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAL41731.2};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAL41731.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL41731.2};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAL41731.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL41731.2};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAL41731.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL41731.2};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAL41731.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAL41731.2};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL41731.2}.
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DR EMBL; AAAB01008807; EAL41731.2; -; Genomic_DNA.
DR RefSeq; XP_564580.2; XM_564580.2.
DR AlphaFoldDB; Q5TX35; -.
DR STRING; 7165.Q5TX35; -.
DR PaxDb; 7165-AGAP007646-PA; -.
DR GeneID; 1269580; -.
DR KEGG; aga:AgaP_AGAP007646; -.
DR VEuPathDB; VectorBase:AGAP007646; -.
DR eggNOG; KOG1030; Eukaryota.
DR HOGENOM; CLU_011170_2_0_1; -.
DR OMA; DCGPTLE; -.
DR OrthoDB; 880291at2759; -.
DR PhylomeDB; Q5TX35; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04042; C2A_MCTP_PRT; 1.
DR CDD; cd08376; C2B_MCTP_PRT; 1.
DR CDD; cd08377; C2C_MCTP_PRT; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR013583; MCTP_C.
DR PANTHER; PTHR45911; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45911:SF4; MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF08372; PRT_C; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 3.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR PROSITE; PS50004; C2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 796..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..324
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 498..621
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 27..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 99479 MW; 390D137A1E3F4787 CRC64;
MYFKRSRLNL ESKCSSLRKH LSKSASELSC NDCGGSGDSP QSSPQRARSA NVPTIPAGVL
QRTHGFFNTL RHRWSRGRSK ERLRGSLGQD LEGRRDSQSD YAADNSSAEH SSSATPHQSP
RHRARTLEDS PLAKGAERNA TMSGTAGVGS INEGASSSGV ASVLKVLTAK VDVEATAGPS
GLSHLTIGGL HKVSEIAGPS GMSGLSPAEE QQRRRETQLR QHSFFQLRVH LISGHGLVAM
DKSGTSDPYV KFKVGGRLLY KSKTVHKDLN PVWDETFVVP VEDPFQPIVI KVFDYDWGLQ
DDFMGSAKLY LTSLELNRAE DLTIKLEDAQ RASKDLGELK LSVTLWPKTQ EDKEQRNPKL
ADASRRLKSQ IWSSVVTIVL IEAKGLPPDA ENGLNDLYVR FRLGNEKYKS KAAYRARWLE
QFDLHLFDDD QLLELVVCGK YNTYGKCTID LRGLARERTH GIWQPLEECT GEVHLMLTIS
GTTASETITD LTAYKEDSKE RALIQSRYIW HKSLQNMRDV GHLTVKVFGA TGLAAADIGG
KSDPFVVLEL INARLQTQTE YKTLTPNWNK IFTFNVKDMS SVLEITVYDE DRDHKVEFLG
KVVIPLLRIR NGEKRWYALK DKKMYTRAKG TQPQVEMTVM WNKLRAALRA LEPKEEKLVQ
QEAKFKRQLF LRNVTRLKAV IMYFIEVGQF VQSCFEWESP IRSFIALVLW VCGCIWNWLI
RWLTGSSSQS TADEYDVASD DEDEEDKEKE EKKTIKERLQ AIQEVSQSVQ NTIGYLASLG
ESVKNTFNFS VPELSWLTAL LLLAACLVLH YVPIRVLLLL WGLVKFSRRI IRPHSVPNNE
VLDLLSRVPD DEEIIMWREL PLHSTPELAR RDPRKKHKVS
//
