ID Q5TYP7_DANRE Unreviewed; 535 AA.
AC Q5TYP7; A0A8N7UY98;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 148.
DE SubName: Full=EH domain-containing protein 3 {ECO:0000313|RefSeq:NP_001038469.1};
DE SubName: Full=EH-domain-containing 3 {ECO:0000313|Ensembl:ENSDARP00000020154};
GN Name=ehd3 {ECO:0000313|Ensembl:ENSDARP00000020154,
GN ECO:0000313|RefSeq:NP_001038469.1,
GN ECO:0000313|ZFIN:ZDB-GENE-041014-352};
GN Synonyms=si:ch211-147c1.2 {ECO:0000313|RefSeq:NP_001038469.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000020154};
RN [1] {ECO:0000313|RefSeq:NP_001038469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038469.1};
RX PubMed=22139419;
RA Gieger C., Radhakrishnan A., Cvejic A., Tang W., Porcu E., Pistis G.,
RA Serbanovic-Canic J., Elling U., Goodall A.H., Labrune Y., Lopez L.M.,
RA Magi R., Meacham S., Okada Y., Pirastu N., Sorice R., Teumer A., Voss K.,
RA Zhang W., Ramirez-Solis R., Bis J.C., Ellinghaus D., Gogele M.,
RA Hottenga J.J., Langenberg C., Kovacs P., O'Reilly P.F., Shin S.Y., Esko T.,
RA Hartiala J., Kanoni S., Murgia F., Parsa A., Stephens J., van der Harst P.,
RA Ellen van der Schoot C., Allayee H., Attwood A., Balkau B., Bastardot F.,
RA Basu S., Baumeister S.E., Biino G., Bomba L., Bonnefond A., Cambien F.,
RA Chambers J.C., Cucca F., D'Adamo P., Davies G., de Boer R.A., de Geus E.J.,
RA Doring A., Elliott P., Erdmann J., Evans D.M., Falchi M., Feng W.,
RA Folsom A.R., Frazer I.H., Gibson Q.D., Glazer N.L., Hammond C.,
RA Hartikainen A.L., Heckbert S.R., Hengstenberg C., Hersch M., Illig T.,
RA Loos R.J., Jolley J., Khaw K.T., Kuhnel B., Kyrtsonis M.C., Lagou V.,
RA Lloyd-Jones H., Lumley T., Mangino M., Maschio A., Mateo Leach I.,
RA McKnight B., Memari Y., Mitchell B.D., Montgomery G.W., Nakamura Y.,
RA Nauck M., Navis G., Nothlings U., Nolte I.M., Porteous D.J., Pouta A.,
RA Pramstaller P.P., Pullat J., Ring S.M., Rotter J.I., Ruggiero D.,
RA Ruokonen A., Sala C., Samani N.J., Sambrook J., Schlessinger D.,
RA Schreiber S., Schunkert H., Scott J., Smith N.L., Snieder H., Starr J.M.,
RA Stumvoll M., Takahashi A., Tang W.H., Taylor K., Tenesa A., Lay Thein S.,
RA Tonjes A., Uda M., Ulivi S., van Veldhuisen D.J., Visscher P.M., Volker U.,
RA Wichmann H.E., Wiggins K.L., Willemsen G., Yang T.P., Hua Zhao J.,
RA Zitting P., Bradley J.R., Dedoussis G.V., Gasparini P., Hazen S.L.,
RA Metspalu A., Pirastu M., Shuldiner A.R., Joost van Pelt L., Zwaginga J.J.,
RA Boomsma D.I., Deary I.J., Franke A., Froguel P., Ganesh S.K.,
RA Jarvelin M.R., Martin N.G., Meisinger C., Psaty B.M., Spector T.D.,
RA Wareham N.J., Akkerman J.W., Ciullo M., Deloukas P., Greinacher A.,
RA Jupe S., Kamatani N., Khadake J., Kooner J.S., Penninger J., Prokopenko I.,
RA Stemple D., Toniolo D., Wernisch L., Sanna S., Hicks A.A., Rendon A.,
RA Ferreira M.A., Ouwehand W.H., Soranzo N.;
RT "New gene functions in megakaryopoiesis and platelet formation.";
RL Nature 480:201-208(2011).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000020154, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000020154};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000020154}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000020154};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001038469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038469.1};
RX PubMed=25686250; DOI=10.1038/ncb3109;
RA Lu Q., Insinna C., Ott C., Stauffer J., Pintado P.A., Rahajeng J., Baxa U.,
RA Walia V., Cuenca A., Hwang Y.S., Daar I.O., Lopes S.,
RA Lippincott-Schwartz J., Jackson P.K., Caplan S., Westlake C.J.;
RT "Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary
RT vesicle formation.";
RL Nat. Cell Biol. 17:228-240(2015).
RN [5] {ECO:0000313|RefSeq:NP_001038469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038469.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001038469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038469.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [7] {ECO:0000313|RefSeq:NP_001038469.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038469.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; BX897693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX957287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038469.1; NM_001045004.1.
DR STRING; 7955.ENSDARP00000020154; -.
DR PaxDb; 7955-ENSDARP00000020154; -.
DR Ensembl; ENSDART00000022694; ENSDARP00000020154; ENSDARG00000007869.
DR Ensembl; ENSDART00000022694.7; ENSDARP00000020154.5; ENSDARG00000007869.8.
DR GeneID; 562949; -.
DR KEGG; dre:562949; -.
DR AGR; ZFIN:ZDB-GENE-041014-352; -.
DR CTD; 30845; -.
DR ZFIN; ZDB-GENE-041014-352; ehd3.
DR eggNOG; KOG1954; Eukaryota.
DR HOGENOM; CLU_017595_1_1_1; -.
DR OMA; LMIGQYS; -.
DR OrthoDB; 12127at2759; -.
DR PhylomeDB; Q5TYP7; -.
DR TreeFam; TF314429; -.
DR Reactome; R-DRE-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000007869; Expressed in retina and 18 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055038; C:recycling endosome membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR CDD; cd00052; EH; 1.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR040990; DUF5600.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR031692; EHD_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11216; EH DOMAIN; 1.
DR PANTHER; PTHR11216:SF161; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A; 1.
DR Pfam; PF18150; DUF5600; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16880; EHD_N; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5TYP7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 55..286
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 444..532
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 476..511
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 535 AA; 60793 MW; 5CCE2DB315AD59D0 CRC64;
MFSWLGTDDR RKKDPEVFQT VSEGLKKLYK TKLLPLEEHY KFHEFHSPAL EDADFDNKPM
VLLVGQYSTG KTSFIRYLLE QDFPGMRIGP EPTTDSFIAV MHGTMEGLIP GNALVVDPKK
PFRKLNAFGN AFLNRFVCAQ LPNPVLESIS VIDTPGILSG EKQRISRGYD FAAVLEWFAE
RVDRIILLFD AHKLDISDEF SEVIKALKNH EDKIRVVLNK ADQIETQQLM RVYGALMWSL
GKIVNTPEVI RVYIGSFWSH PLLIPDNRKL FEAEEQDLFK DIQSLPRNAA LRKLNDLIKR
ARLAKVHAYI ISSLKKEMPS VFGKDNKKKE LINSLGEIYS RIEREHQISP GDFPNLKKMQ
EQLQAHDLNK FQPLKMKLLD TVDDMLAHDI AQLMVLVRQE ETQRPNQVVK GGAFEGTMNG
PFGHGYGEGA GEGIDEVEWV VARDKPMYDE IFYTLSPVNG KVTGANAKRE MVKSKLPNTV
LGKIWKLADI DKDGMLDDEE FALANHLIKV KLEGHELPSD LPGHLVPPSK RKVPE
//
