ID Q5TZ86_DANRE Unreviewed; 496 AA.
AC Q5TZ86; B3DGW6;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE SubName: Full=Cytochrome P450, family 2, subfamily J, polypeptide 23 {ECO:0000313|EMBL:AAI62546.1};
DE SubName: Full=Cytochrome P450, family 2, subfamily P, polypeptide 8 {ECO:0000313|Ensembl:ENSDARP00000063107, ECO:0000313|RefSeq:NP_001076504.1};
GN Name=cyp2p8 {ECO:0000313|Ensembl:ENSDARP00000063107,
GN ECO:0000313|RefSeq:NP_001076504.1,
GN ECO:0000313|ZFIN:ZDB-GENE-061030-1};
GN Synonyms=cyp2j23 {ECO:0000313|EMBL:AAI62546.1}, si:dkey-183n20.5
GN {ECO:0000313|RefSeq:NP_001076504.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62546.1};
RN [1] {ECO:0000313|EMBL:AAI62546.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21087487;
RA Goldstone J.V., McArthur A.G., Kubota A., Zanette J., Parente T.,
RA Jonsson M.E., Nelson D.R., Stegeman J.J.;
RT "Identification and developmental expression of the full complement of
RT Cytochrome P450 genes in Zebrafish.";
RL BMC Genomics 11:643-643(2010).
RN [3] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21116621;
RA Kirischian N., McArthur A.G., Jesuthasan C., Krattenmacher B., Wilson J.Y.;
RT "Phylogenetic and functional analysis of the vertebrate cytochrome p450 2
RT family.";
RL J. Mol. Evol. 72:56-71(2011).
RN [4] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21445457;
RA Li Z.H., Alex D., Siu S.O., Chu I.K., Renn J., Winkler C., Lou S.,
RA Tsui S.K., Zhao H.Y., Yan W.R., Mahady G.B., Li G.H., Kwan Y.W., Wang Y.T.,
RA Lee S.M.;
RT "Combined in vivo imaging and omics approaches reveal metabolism of
RT icaritin and its glycosides in zebrafish larvae.";
RL Mol. Biosyst. 7:2128-2138(2011).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000063107, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063107};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000063107}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063107};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28411468;
RA Puthumana J., Kim B.M., Jeong C.B., Kim D.H., Kang H.M., Jung J.H.,
RA Kim I.C., Hwang U.K., Lee J.S.;
RT "Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P
RT gene families in the mangrove killifish Kryptolebias marmoratus genome:
RT Identification and expression in response to B[alpha]P, BPA, OP, and NP.";
RL Aquat. Toxicol. 187:132-140(2017).
RN [9] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [10] {ECO:0000313|RefSeq:NP_001076504.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29909292;
RA Liu Y., Junaid M., Wang Y., Tang Y.M., Bian W.P., Xiong W.X., Huang H.Y.,
RA Chen C.D., Pei D.S.;
RT "New toxicogenetic insights and ranking of the selected pharmaceuticals
RT belong to the three different classes: A toxicity estimation to
RT confirmation approach.";
RL Aquat. Toxicol. 201:151-161(2018).
RN [11] {ECO:0000313|RefSeq:NP_001076504.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; BX322665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC162546; AAI62546.1; -; mRNA.
DR EMBL; BC162547; AAI62547.1; -; mRNA.
DR RefSeq; NP_001076504.1; NM_001083035.2.
DR STRING; 7955.ENSDARP00000063107; -.
DR PaxDb; 7955-ENSDARP00000063107; -.
DR Ensembl; ENSDART00000063108; ENSDARP00000063107; ENSDARG00000042982.
DR Ensembl; ENSDART00000063108.5; ENSDARP00000063107.4; ENSDARG00000042982.5.
DR GeneID; 100034366; -.
DR KEGG; dre:100034366; -.
DR AGR; ZFIN:ZDB-GENE-061030-1; -.
DR CTD; 100034366; -.
DR ZFIN; ZDB-GENE-061030-1; cyp2p8.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR OMA; MEFQETA; -.
DR OrthoDB; 2900138at2759; -.
DR TreeFam; TF352043; -.
DR Reactome; R-DRE-211935; Fatty acids.
DR Reactome; R-DRE-211958; Miscellaneous substrates.
DR Reactome; R-DRE-211981; Xenobiotics.
DR Reactome; R-DRE-211999; CYP2E1 reactions.
DR Reactome; R-DRE-9027307; Biosynthesis of maresin-like SPMs.
DR Reactome; R-DRE-9749641; Aspirin ADME.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000042982; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR GO; GO:0006082; P:organic acid metabolic process; IBA:GO_Central.
DR GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR CDD; cd11026; CYP2; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF301; CYP2J25 PROTEIN-RELATED; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01686; EP450ICYP2D.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 496 AA; 56807 MW; 76C8DA756F28BC4B CRC64;
MDLWYLYEWI DIKSILIFLC VFLLLGDYIK NKAPKNFPPG PWSLPIIGDL HHIDNSKIHL
QFTKFAERYG NIFSFRLFGP RIVVLNGYNL VKEVYIKQGD NLADRPVLPL FYEIVGDKGL
ILSSGYKWKH QRRFALSTLR NFGLGKKSLE PSINVECGFL NEAISNEQGR PFDPRLLLNN
AVSNVICVLV FGNRFDYSDH HFQTLLKNIS EAVYLEGSIC NQLYNMFPWL MERLPGPHKT
IITLWRKVTD FVREKVNEHR VDYDPSNPRD YIDCFLTEME KLKDDTAAGF DVENLCICSL
DLFVAGTETT STTLYWGLLY MIKYPEIQAK VQEEIDAVVG GSRQPSVSDR DNMPYTNAVI
HEIQRMGNIA PINLARSTSE DTQIGNYSIP KGTMVTSNLT SVLFDESEWE TPHSFNPGHF
LDAEGKFRRR DAFLPFSLGK RVCLGEQLAR MELFLFFSSL LQRFTFSPPA GVEPSLDYKM
GGTHCPKPFK LCAVPR
//
