ID Q5U4H9_MOUSE Unreviewed; 625 AA.
AC Q5U4H9;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Nuclear receptor coactivator 4 {ECO:0000313|EMBL:AAH85086.1, ECO:0000313|Ensembl:ENSMUSP00000107625.4};
GN Name=Ncoa4 {ECO:0000313|EMBL:AAH85086.1,
GN ECO:0000313|Ensembl:ENSMUSP00000107625.4,
GN ECO:0000313|MGI:MGI:1350932};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH85086.1};
RN [1] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:AAH85086.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH85086.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [9] {ECO:0000313|EMBL:BAE26774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/C {ECO:0000313|EMBL:BAE27129.1}, and C57BL/6J
RC {ECO:0000313|EMBL:BAE26774.1};
RC TISSUE=Amnion {ECO:0000313|EMBL:BAE27214.1}, and Placenta
RC {ECO:0000313|EMBL:BAE26774.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [10] {ECO:0000313|Ensembl:ENSMUSP00000107625.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107625.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [11] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [12] {ECO:0000313|Ensembl:ENSMUSP00000107625.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107625.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC085086; AAH85086.1; -; mRNA.
DR EMBL; AK145945; BAE26774.1; -; mRNA.
DR EMBL; AK146384; BAE27129.1; -; mRNA.
DR EMBL; AK146498; BAE27214.1; -; mRNA.
DR EMBL; AK146646; BAE27327.1; -; mRNA.
DR RefSeq; NP_001029160.1; NM_001033988.2.
DR RefSeq; NP_062718.2; NM_019744.4.
DR STRING; 10090.ENSMUSP00000126071; -.
DR PaxDb; 10090-ENSMUSP00000126071; -.
DR ProteomicsDB; 343124; -.
DR Antibodypedia; 72715; 485 antibodies from 34 providers.
DR DNASU; 27057; -.
DR Ensembl; ENSMUST00000111994.10; ENSMUSP00000107625.4; ENSMUSG00000056234.16.
DR Ensembl; ENSMUST00000163336.8; ENSMUSP00000126071.2; ENSMUSG00000056234.16.
DR GeneID; 27057; -.
DR KEGG; mmu:27057; -.
DR UCSC; uc007syj.2; mouse.
DR AGR; MGI:1350932; -.
DR CTD; 8031; -.
DR MGI; MGI:1350932; Ncoa4.
DR VEuPathDB; HostDB:ENSMUSG00000056234; -.
DR eggNOG; ENOG502QQ6V; Eukaryota.
DR GeneTree; ENSGT00390000008403; -.
DR HOGENOM; CLU_034170_0_0_1; -.
DR OMA; FPPDCYG; -.
DR OrthoDB; 3016401at2759; -.
DR TreeFam; TF333204; -.
DR BioGRID-ORCS; 27057; 7 hits in 81 CRISPR screens.
DR ChiTaRS; Ncoa4; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000056234; Expressed in spermatid and 68 other cell types or tissues.
DR GO; GO:0044754; C:autolysosome; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IMP:MGI.
DR GO; GO:0006622; P:protein targeting to lysosome; ISO:MGI.
DR GO; GO:0009725; P:response to hormone; IBA:GO_Central.
DR InterPro; IPR022174; ARA70.
DR InterPro; IPR039947; NCoA-4.
DR PANTHER; PTHR17085; NUCLEAR RECEPTOR COACTIVATOR 4; 1.
DR PANTHER; PTHR17085:SF3; NUCLEAR RECEPTOR COACTIVATOR 4; 1.
DR Pfam; PF12489; ARA70; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q5U4H9,
KW ECO:0007829|MaxQB:Q5U4H9}; Receptor {ECO:0000313|EMBL:AAH85086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 38..145
FT /note="Nuclear coactivator"
FT /evidence="ECO:0000259|Pfam:PF12489"
FT DOMAIN 199..330
FT /note="Nuclear coactivator"
FT /evidence="ECO:0000259|Pfam:PF12489"
SQ SEQUENCE 625 AA; 70381 MW; E782DFCCB0132D93 CRC64;
MNTSLEQSGC YSNRETLLRC SDARRELELA IGGVLRAEQQ IKDNLREVKA QIHSCISRHL
ECLRSREVWL NEQVDLIYQL KEETLQQQAQ QLYWLMGQFN CLIHQLEYTQ NKDLANQVSV
CLERLGSLAL KPEDSTVLLF EADTSALRQT ITTFGSLKTI QIPEHLMAHA SSSSIGPFLE
KRGYIQVPEQ KSASSGTAVS LSEWLLVSKP AIGLQAPYVP STNPQDWLIP KQTSENSQTS
ARACSFFSDA WGNLKGLENW LLNSHQQEIA GKPSSSKCNS HCSTSSFSPE AEKAEDVELL
DQDELDLSDW LVTPQEPCEL EKPVDGSWET SEKFKLLFQV FREPYNVSDW LVKPDSCTNC
QGNQPRGVEI ENLGNLKCLN DHLEAKKSVS VPGATISDGW LAQNHQDTWK VEEVCKANEP
CTSFAECVCD DNCEKEAMYK WLLKKGGKDK NGMPMEPKSE PEKHRESLTL WLCPSRNELT
EQAKAPKAMA PARIADSFHV IKNSSLSEWL MGPTCKGGPK DVPNTEERAG KEMLQSSMAT
SWCPFNTADW VLPGKKVGSL SQFPSGEDKW LLRKKAQEAF LNSPLQEERN FRPDCYGLPA
VCDLFACMQL KVDKEKWLYR TPLQM
//
