ID Q5UYF4_HALMA Unreviewed; 503 AA.
AC Q5UYF4;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
GN Name=pheS {ECO:0000313|EMBL:AAV47699.1};
GN OrderedLocusNames=rrnAC2966 {ECO:0000313|EMBL:AAV47699.1};
GN ORFNames=E6P14_16520 {ECO:0000313|EMBL:QCP92383.1};
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569 {ECO:0000313|EMBL:AAV47699.1, ECO:0000313|Proteomes:UP000001169};
RN [1] {ECO:0000313|EMBL:AAV47699.1, ECO:0000313|Proteomes:UP000001169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:AAV47699.1}, and ATCC 43049 / DSM
RC 3752 / JCM 8966 / VKM B-1809 {ECO:0000313|Proteomes:UP000001169};
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
RN [2] {ECO:0000313|EMBL:QCP92383.1, ECO:0000313|Proteomes:UP000298722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:QCP92383.1,
RC ECO:0000313|Proteomes:UP000298722};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Phe-tRNA synthetase alpha subunit type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00006703}.
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DR EMBL; AY596297; AAV47699.1; -; Genomic_DNA.
DR EMBL; CP039138; QCP92383.1; -; Genomic_DNA.
DR RefSeq; WP_011224539.1; NZ_CP039138.1.
DR AlphaFoldDB; Q5UYF4; -.
DR STRING; 272569.rrnAC2966; -.
DR PaxDb; 272569-rrnAC2966; -.
DR EnsemblBacteria; AAV47699; AAV47699; rrnAC2966.
DR GeneID; 40153794; -.
DR KEGG; hma:rrnAC2966; -.
DR PATRIC; fig|272569.17.peg.3526; -.
DR eggNOG; arCOG00410; Archaea.
DR HOGENOM; CLU_025086_2_2_2; -.
DR Proteomes; UP000001169; Chromosome I.
DR Proteomes; UP000298722; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00496; PheRS_alpha_core; 1.
DR Gene3D; 1.10.10.2320; -; 1.
DR Gene3D; 1.10.10.2330; -; 1.
DR Gene3D; 3.30.1370.240; -; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR NCBIfam; TIGR00468; pheS; 1.
DR PANTHER; PTHR11538:SF40; PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01409; tRNA-synt_2d; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:AAV47699.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001169}.
FT DOMAIN 245..498
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 503 AA; 55915 MW; 9B5DA9196F3F8435 CRC64;
MKRPQAQVAV LQAADAQEDR RIDDVAAEAD LKPEAATRAA FELEADGLLA VSEETLEHYE
LTEEGDQYVR ESLPEQDLYE AAIDAGAADG PVQMGQVIGA SGLEGGAVDI ALSNYARKAY
GEIDSGEITA NQDADPGSDP EMLALEAVAD GRVEDADADA LEQLERRGLL DVREETVRSV
QLTDDGVTAL MEGVEAAETV DQLTPEMLTS GEWEDVAFTE YNVEADAEDV SHGKEHILRQ
TANRVKDTLV GMGFSEMEGP HADAQFWIND CLFMPQDHPA RTHWDQFALE EPEEIGHLPP
DLVERVRSAH KEGVGPDGEG YHSPWTEDIA RGMDLRGHTT SLSMRYLSGH QVGELDPPER
YFSVEKVYRN DTLDPTHLLE FFQIEGWVMA EDLSVRDLMG TFTEFYEQFG ITDLEFKPHY
NPYTEPSFEL FGTHPETGEV VEVGNSGIFR DEVLTPLGVD CDVMAWGLSL ERLLMLMYGF
EDIRDVHGTL CDLELLRETE VIR
//
