ID Q5V3T3_HALMA Unreviewed; 445 AA.
AC Q5V3T3;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN Name=menF {ECO:0000313|EMBL:AAV45819.1};
GN OrderedLocusNames=rrnAC0837 {ECO:0000313|EMBL:AAV45819.1};
GN ORFNames=E6P14_06865 {ECO:0000313|EMBL:QCP90592.1};
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569 {ECO:0000313|EMBL:AAV45819.1, ECO:0000313|Proteomes:UP000001169};
RN [1] {ECO:0000313|EMBL:AAV45819.1, ECO:0000313|Proteomes:UP000001169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:AAV45819.1}, and ATCC 43049 / DSM
RC 3752 / JCM 8966 / VKM B-1809 {ECO:0000313|Proteomes:UP000001169};
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
RN [2] {ECO:0000313|EMBL:QCP90592.1, ECO:0000313|Proteomes:UP000298722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:QCP90592.1,
RC ECO:0000313|Proteomes:UP000298722};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
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DR EMBL; AY596297; AAV45819.1; -; Genomic_DNA.
DR EMBL; CP039138; QCP90592.1; -; Genomic_DNA.
DR RefSeq; WP_011223264.1; NZ_CP039138.1.
DR AlphaFoldDB; Q5V3T3; -.
DR STRING; 272569.rrnAC0837; -.
DR PaxDb; 272569-rrnAC0837; -.
DR EnsemblBacteria; AAV45819; AAV45819; rrnAC0837.
DR GeneID; 40151862; -.
DR KEGG; hma:rrnAC0837; -.
DR PATRIC; fig|272569.17.peg.1576; -.
DR eggNOG; arCOG02015; Archaea.
DR HOGENOM; CLU_006493_8_4_2; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000001169; Chromosome I.
DR Proteomes; UP000298722; Chromosome.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AAV45819.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001169}.
FT DOMAIN 183..436
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 163..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 48339 MW; CD32DB27FF626F8D CRC64;
MEPLRGDETT VGETTVVARG CRLDDAPVRS VLVTDARPRF FWAAGTESIA ARGSAATVTA
DGQSRFDDVR TAVEALFDDC SVPDSLPSIA RPRAFGGFAF HNGTHEGEDS PWDGFPSAAF
FLPEIQVTRR DDDAWLTTVA TGPEAATEAE ALLEEWRDRL VADSERNPGT PPGISHRKRT
PTQDGWREQV AAATESIDRG ELQKVVLAQS LSATLDAELS VPDVMARLSK TYPDCYRFML
SPDSGGTFFG ATPERLVSVR GRTVRTEALA GSTGRGDTPA EDEWLAAELL DSEKDRHEQK
LVADAIRDQL EPFASTVRIG DRTVRRLATV QHLRTSITAE LDDDEHVLSL VEALHPTPAV
GGLPPDAALR TIRETEAFDR GWYAAPVGWV DAAGNGTFAV GIRSAVATER EATLFAGAGI
VADSDPDREW DEVQLKYRPI LDELE
//
