ID Q5V4B4_HALMA Unreviewed; 331 AA.
AC Q5V4B4;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Signal peptide peptidase SppA {ECO:0000313|EMBL:AAV45638.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:AAV45638.1};
GN Name=sppA {ECO:0000313|EMBL:AAV45638.1};
GN OrderedLocusNames=rrnAC0630 {ECO:0000313|EMBL:AAV45638.1};
GN ORFNames=E6P14_05945 {ECO:0000313|EMBL:QCP90420.1};
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569 {ECO:0000313|EMBL:AAV45638.1, ECO:0000313|Proteomes:UP000001169};
RN [1] {ECO:0000313|EMBL:AAV45638.1, ECO:0000313|Proteomes:UP000001169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:AAV45638.1}, and ATCC 43049 / DSM
RC 3752 / JCM 8966 / VKM B-1809 {ECO:0000313|Proteomes:UP000001169};
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
RN [2] {ECO:0000313|EMBL:QCP90420.1, ECO:0000313|Proteomes:UP000298722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:QCP90420.1,
RC ECO:0000313|Proteomes:UP000298722};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
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DR EMBL; AY596297; AAV45638.1; -; Genomic_DNA.
DR EMBL; CP039138; QCP90420.1; -; Genomic_DNA.
DR RefSeq; WP_004961999.1; NZ_CP039138.1.
DR AlphaFoldDB; Q5V4B4; -.
DR STRING; 272569.rrnAC0630; -.
DR PaxDb; 272569-rrnAC0630; -.
DR EnsemblBacteria; AAV45638; AAV45638; rrnAC0630.
DR GeneID; 64822695; -.
DR KEGG; hma:rrnAC0630; -.
DR PATRIC; fig|272569.17.peg.1385; -.
DR eggNOG; arCOG01311; Archaea.
DR HOGENOM; CLU_046540_0_2_2; -.
DR Proteomes; UP000001169; Chromosome I.
DR Proteomes; UP000298722; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR42987; PEPTIDASE S49; 1.
DR PANTHER; PTHR42987:SF4; PROTEASE SLR0021-RELATED; 1.
DR Pfam; PF01343; Peptidase_S49; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AAV45638.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001169};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..281
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
SQ SEQUENCE 331 AA; 34784 MW; 9B6E36F41A373CF8 CRC64;
MAGADDIVRG LLVVLVVGIG TVLGWVLFVR TPDNLAQLFG VLLVVAVAVA TARIGSNIAG
SLLPAHNVAE VAVEGPISRD GGGGITSPPV GASADDIVEQ IERADSDRGS EALLLKLNTP
GGEIVPSEDI RIAAEQFDGP TIAYATDVCA SGGYDIAAGC DELWAREGSI VGSIGVVGSR
VNAKELADRV GLSYEQFTAG EYKDAGVPLK EMTADEREYL QSIVDDYYDQ FIDTVAEGRE
MDAEALKDTE ARIFLGDEAE ERGLVDRLGT RDDVEASLEQ RLGEDVTIKE YEPERGLTGK
LRGGAQQVAF ALGAGIAGVA DGDIEGLSFR R
//
