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Database: UniProt
Entry: Q5WJB8_BACSK
LinkDB: Q5WJB8_BACSK
Original site: Q5WJB8_BACSK 
ID   Q5WJB8_BACSK            Unreviewed;       366 AA.
AC   Q5WJB8;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   26-FEB-2020, entry version 77.
DE   SubName: Full=Naringenin-chalcone synthase {ECO:0000313|EMBL:BAD63537.1};
DE            EC=2.3.1.74 {ECO:0000313|EMBL:BAD63537.1};
GN   Name=bcsA {ECO:0000313|EMBL:BAD63537.1};
GN   OrderedLocusNames=ABC0998 {ECO:0000313|EMBL:BAD63537.1};
OS   Bacillus clausii (strain KSM-K16).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=66692 {ECO:0000313|EMBL:BAD63537.1, ECO:0000313|Proteomes:UP000001168};
RN   [1] {ECO:0000313|EMBL:BAD63537.1, ECO:0000313|Proteomes:UP000001168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16 {ECO:0000313|EMBL:BAD63537.1,
RC   ECO:0000313|Proteomes:UP000001168};
RA   Hakamada Y., Kobayashi T., Hitomi J., Kawai S., Ito S.;
RT   "Molecular cloning and nucleotide sequence of the gene for an alkaline
RT   protease from the alkalophilic Bacillus sp. KSM-K16.";
RL   J. Ferment. Bioeng. 78:105-108(1994).
RN   [2] {ECO:0000313|EMBL:BAD63537.1, ECO:0000313|Proteomes:UP000001168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16 {ECO:0000313|EMBL:BAD63537.1,
RC   ECO:0000313|Proteomes:UP000001168};
RX   PubMed=7632397; DOI=10.1007/s002530050437;
RA   Kobayashi T., Hakamada Y., Adachi S., Hitomi J., Yoshimatsu T., Koike K.,
RA   Kawai S., Ito S.;
RT   "Purification and properties of an alkaline protease from alkalophilic
RT   Bacillus sp. KSM-K16.";
RL   Appl. Microbiol. Biotechnol. 43:473-481(1995).
RN   [3] {ECO:0000313|EMBL:BAD63537.1, ECO:0000313|Proteomes:UP000001168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16 {ECO:0000313|EMBL:BAD63537.1,
RC   ECO:0000313|Proteomes:UP000001168};
RX   PubMed=9278275; DOI=10.1093/protein/10.6.627;
RA   Shirai T., Suzuki A., Yamane T., Ashida T., Kobayashi T., Ito S.;
RT   "High-resolution crystal structure of M-protease: phylogeny aided analysis
RT   of the high-alkaline adaptation mechanism.";
RL   Protein Eng. 10:627-634(1997).
RN   [4] {ECO:0000313|Proteomes:UP000001168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16 {ECO:0000313|Proteomes:UP000001168};
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:BAD63537.1, ECO:0000313|Proteomes:UP000001168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16 {ECO:0000313|EMBL:BAD63537.1,
RC   ECO:0000313|Proteomes:UP000001168};
RX   PubMed=17429572; DOI=10.1007/s00792-007-0074-1;
RA   Kageyama Y., Takaki Y., Shimamura S., Nishi S., Nogi Y., Uchimura K.,
RA   Kobayashi T., Hitomi J., Ozaki K., Kawai S., Ito S., Horikoshi K.;
RT   "Intragenomic diversity of the V1 regions of 16S rRNA genes in high-
RT   alkaline protease-producing Bacillus clausii spp.";
RL   Extremophiles 11:597-603(2007).
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DR   EMBL; AP006627; BAD63537.1; -; Genomic_DNA.
DR   RefSeq; WP_011245853.1; NC_006582.1.
DR   STRING; 66692.ABC0998; -.
DR   EnsemblBacteria; BAD63537; BAD63537; ABC0998.
DR   GeneID; 34043605; -.
DR   KEGG; bcl:ABC0998; -.
DR   eggNOG; ENOG41065KQ; Bacteria.
DR   eggNOG; COG3424; LUCA.
DR   HOGENOM; CLU_034992_0_1_9; -.
DR   KO; K16167; -.
DR   OMA; PIWGLGC; -.
DR   OrthoDB; 872193at2; -.
DR   BioCyc; BCLA66692:G1G25-1069-MONOMER; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synth_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synthase_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000313|EMBL:BAD63537.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001168};
KW   Transferase {ECO:0000313|EMBL:BAD63537.1}.
FT   DOMAIN          3..204
FT                   /note="Chal_sti_synt_N"
FT                   /evidence="ECO:0000259|Pfam:PF00195"
FT   DOMAIN          224..359
FT                   /note="Chal_sti_synt_C"
FT                   /evidence="ECO:0000259|Pfam:PF02797"
FT   ACT_SITE        144
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ   SEQUENCE   366 AA;  40178 MW;  2C62069A15D73B4C CRC64;
     MPTILSVSTY DPPHPIKQEQ TVEFARELFA ESFSDIERLL NVFANGEIEK RHFSVPLEWF
     QTSHRLGERN DLFIEKATDY SVEAVKSCLA NGHFVSRTIA PEEIDAIIFV SSSGMATPSI
     DARIMNKLPF RPETKRLPIW GLGCAGGAAG LSRAYDYCLA HPETAVLVVC AELCGLTFQK
     EDQSKSNLIG TSLFADGVAC ALVAGHASPL LADAAQAYRP VIRATQSVLM PDSEDVMGWD
     VRDNGLNVIF SRHIPTLVAQ WLKPNVEELL RQEGKEIGEI NAFIAHPGGK KVLEAYEKAL
     GFPEEMTMLS RKVLKEHGNM SSPTVLYVLK ESMEETHKHG DVGLVAALGP GFCSEMLVLE
     WAGGLH
//
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