ID Q5WRR6_CAEEL Unreviewed; 515 AA.
AC Q5WRR6;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=PDZ domain-containing protein {ECO:0000313|EMBL:CCD67923.1};
GN Name=stn-2 {ECO:0000313|EMBL:CCD67923.1,
GN ECO:0000313|WormBase:F27D9.8};
GN ORFNames=CELE_F27D9.8 {ECO:0000313|EMBL:CCD67923.1}, F27D9.8
GN {ECO:0000313|WormBase:F27D9.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD67923.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD67923.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD67923.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the syntrophin family.
CC {ECO:0000256|ARBA:ARBA00010798}.
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DR EMBL; BX284606; CCD67923.1; -; Genomic_DNA.
DR RefSeq; NP_001024610.1; NM_001029439.2.
DR AlphaFoldDB; Q5WRR6; -.
DR SMR; Q5WRR6; -.
DR IntAct; Q5WRR6; 1.
DR STRING; 6239.F27D9.8b.1; -.
DR EPD; Q5WRR6; -.
DR PaxDb; 6239-F27D9-8b; -.
DR EnsemblMetazoa; F27D9.8.1; F27D9.8.1; WBGene00017866.
DR GeneID; 181029; -.
DR KEGG; cel:CELE_F27D9.8; -.
DR UCSC; F27D9.8a; c. elegans.
DR AGR; WB:WBGene00017866; -.
DR WormBase; F27D9.8; CE37639; WBGene00017866; stn-2.
DR eggNOG; KOG3549; Eukaryota.
DR GeneTree; ENSGT00950000182863; -.
DR HOGENOM; CLU_039445_0_0_1; -.
DR InParanoid; Q5WRR6; -.
DR OMA; YVTRYLW; -.
DR OrthoDB; 2906429at2759; -.
DR PhylomeDB; Q5WRR6; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00017866; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0044297; C:cell body; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR GO; GO:0030017; C:sarcomere; IDA:WormBase.
DR GO; GO:0050839; F:cell adhesion molecule binding; IPI:WormBase.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00821; PH; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR041428; PHsplit_syntrophin.
DR InterPro; IPR015482; Syntrophin.
DR PANTHER; PTHR10554:SF1; FI16515P1; 1.
DR PANTHER; PTHR10554; SYNTROPHIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF18012; PH_17; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Proteomics identification {ECO:0007829|EPD:Q5WRR6,
KW ECO:0007829|PeptideAtlas:Q5WRR6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 65..150
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 171..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 58405 MW; 2D755C93C279AFB8 CRC64;
MSVTKSHHNL DVVHHGIVLI SDGNATSRSS RLLLSKDELC IQVIDDGTAE PEEAKETFLE
NATRQVVIVK KPDSGFGLSI KGGSENAQNM PIVISKIFKG LPADECGELF IGDAIVEVNG
ISIEGQSHDE VVNMLKSSGD QVTLGVRHFT HMTPFLKPAQ SLQPDGTLDQ LFDGRSTRSH
KAQSESRLSD SKWQQHIDGR EKKWKTLTSL PLAMAYVTRY LWGTDNIRTN SFEVRAVDGR
SSGIVHCEDT SALEQWISHI SKHILSLNQK SIKMSNKYLH QSEQISYIGW VNEYLNDDDQ
EELKIRWQPR FLILKGSDVC FFDVPPLNSE DLNKCVYLYK CYDVAVKQVP NSSPRRDKRD
NCFLIETPLQ VPNHYLSFEA VSAFELFEQA YYRTVYNTIS QMQSRTFACN FEGRASGIVF
DIKQGISLYD IPTKSYIWQY RFRDLQAVAD DGKLCVQLSF NDDRSLNSDR IEVKDIECED
VVTVVFNLHS FVLARIVSTD PDYLKANRYV GNAED
//
