ID Q5XGD1_XENTR Unreviewed; 163 AA.
AC Q5XGD1;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Epithelial membrane protein 3 {ECO:0000313|EMBL:AAH84511.1, ECO:0000313|Ensembl:ENSXETP00000042569};
GN Name=emp3 {ECO:0000313|EMBL:AAH84511.1,
GN ECO:0000313|Ensembl:ENSXETP00000042569,
GN ECO:0000313|RefSeq:NP_001011113.1,
GN ECO:0000313|Xenbase:XB-GENE-952486};
GN Synonyms=ymp {ECO:0000313|RefSeq:NP_001011113.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH84511.1};
RN [1] {ECO:0000313|RefSeq:NP_001011113.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH84511.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH84511.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000042569}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000042569};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000042569}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001011113.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363088}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363088}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family.
CC {ECO:0000256|ARBA:ARBA00006864, ECO:0000256|RuleBase:RU363088}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363088}.
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DR EMBL; BC084511; AAH84511.1; -; mRNA.
DR RefSeq; NP_001011113.1; NM_001011113.2.
DR STRING; 8364.ENSXETP00000004512; -.
DR PaxDb; 8364-ENSXETP00000042569; -.
DR DNASU; 780308; -.
DR Ensembl; ENSXETT00000042569; ENSXETP00000042569; ENSXETG00000010619.
DR GeneID; 496526; -.
DR KEGG; xtr:496526; -.
DR AGR; Xenbase:XB-GENE-952486; -.
DR CTD; 2014; -.
DR Xenbase; XB-GENE-952486; emp3.
DR eggNOG; ENOG502RZP6; Eukaryota.
DR HOGENOM; CLU_138632_1_0_1; -.
DR OMA; QLYTMKR; -.
DR OrthoDB; 4195542at2759; -.
DR TreeFam; TF330414; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000010619; Expressed in skeletal muscle tissue and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR003934; EMP_3.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF8; EPITHELIAL MEMBRANE PROTEIN 3; 1.
DR PANTHER; PTHR10671; EPITHELIAL MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01456; EPMEMPROT3.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363088};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363088};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363088}.
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
SQ SEQUENCE 163 AA; 18561 MW; DAB4B47C53A4D328 CRC64;
MSFLLFGVTA LHLIILVILF VATLDNSWWV FSEEETVNLW YDCLLDNNTG VWLCSSVSTN
EWFHAVQALM VLAVLFSSFS FMLFMCQLYT MERGGLFYAT GVFQILASLA VFSGAVIYAT
HVTEFHPERA KSGYFGHCFV LAWVAFPLSI LSGIMYIHLR KRE
//
