ID Q5XGD8_XENTR Unreviewed; 340 AA.
AC Q5XGD8; K9J809;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Guanine nucleotide binding protein, beta 3 {ECO:0000313|EMBL:AAH84504.1};
DE SubName: Full=Guanine nucleotide-binding protein (G protein), beta polypeptide 3 {ECO:0000313|Ensembl:ENSXETP00000020865, ECO:0000313|Ensembl:ENSXETP00000108762};
DE SubName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 {ECO:0000313|RefSeq:NP_001011107.1};
GN Name=gnb3 {ECO:0000313|EMBL:AAH84504.1,
GN ECO:0000313|Ensembl:ENSXETP00000020865,
GN ECO:0000313|RefSeq:NP_001011107.1,
GN ECO:0000313|Xenbase:XB-GENE-956713};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH84504.1};
RN [1] {ECO:0000313|RefSeq:NP_001011107.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH84504.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH84504.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000020865}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000020865};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000108762}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001011107.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC {ECO:0000256|ARBA:ARBA00009768}.
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DR EMBL; BC084504; AAH84504.1; -; mRNA.
DR RefSeq; NP_001011107.1; NM_001011107.1.
DR DNASU; 496520; -.
DR Ensembl; ENSXETT00000020865; ENSXETP00000020865; ENSXETG00000009466.
DR Ensembl; ENSXETT00000124534; ENSXETP00000108762; ENSXETG00000009466.
DR GeneID; 496520; -.
DR KEGG; xtr:496520; -.
DR AGR; Xenbase:XB-GENE-956713; -.
DR CTD; 2784; -.
DR Xenbase; XB-GENE-956713; gnb3.
DR eggNOG; KOG0286; Eukaryota.
DR HOGENOM; CLU_000288_57_34_1; -.
DR OMA; AKIYACH; -.
DR OrthoDB; 102097at2759; -.
DR TreeFam; TF106149; -.
DR Reactome; R-XTR-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-XTR-202040; G-protein activation.
DR Reactome; R-XTR-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-XTR-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
DR Reactome; R-XTR-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-XTR-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-XTR-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-XTR-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-XTR-4086398; Ca2+ pathway.
DR Reactome; R-XTR-416476; G alpha (q) signalling events.
DR Reactome; R-XTR-416482; G alpha (12/13) signalling events.
DR Reactome; R-XTR-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-XTR-418555; G alpha (s) signalling events.
DR Reactome; R-XTR-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-XTR-418594; G alpha (i) signalling events.
DR Reactome; R-XTR-418597; G alpha (z) signalling events.
DR Reactome; R-XTR-420092; Glucagon-type ligand receptors.
DR Reactome; R-XTR-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-XTR-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-XTR-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-XTR-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-XTR-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-XTR-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-XTR-9634597; GPER1 signaling.
DR Reactome; R-XTR-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR Reactome; R-XTR-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000009466; Expressed in neurula embryo and 6 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19850; GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA; 1.
DR PANTHER; PTHR19850:SF31; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-3; 1.
DR Pfam; PF00400; WD40; 7.
DR PIRSF; PIRSF002394; GN-bd_beta; 1.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 51..92
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 139..179
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 180..221
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 222..263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 308..340
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT COILED 1..31
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 340 AA; 37411 MW; F719B6F5D8FB1FD5 CRC64;
MGELEQLRQE AEALKKQIAE ARKQCADTTL EQTTGGMEVV GRIQLRTRRT LRGHLAKIYA
MHWSTDARLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM
CSIYNLKTRE GNVRVSRELA AHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQKTVF
TGHTGDCMSL AVSPDFNLFI SGACDASAKL WDVRQGECRQ TFTGHESDIN AICFFPSGQA
ICTGSDDATC RMFDLRADQE ISVYSQDSII CGITSVSFSL SGRLLFAGYD DFNCNIWDSL
KRERVGVLSG HDNRVSCLGV TSDGMAVATG SWDSFLKIWN
//
