GenomeNet

Database: UniProt
Entry: Q5XH36
LinkDB: Q5XH36
Original site: Q5XH36 
ID   CRE2A_XENLA             Reviewed;         361 AA.
AC   Q5XH36;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   16-JAN-2019, entry version 73.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2-A;
DE   Flags: Precursor;
GN   Name=creld2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in neuronal acetylcholine receptor
CC       transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
DR   EMBL; BC084239; AAH84239.1; -; mRNA.
DR   RefSeq; NP_001088243.1; NM_001094774.1.
DR   UniGene; Xl.65177; -.
DR   ProteinModelPortal; Q5XH36; -.
DR   SMR; Q5XH36; -.
DR   PRIDE; Q5XH36; -.
DR   GeneID; 495074; -.
DR   KEGG; xla:495074; -.
DR   CTD; 495074; -.
DR   Xenbase; XB-GENE-999017; creld2.
DR   HOVERGEN; HBG081344; -.
DR   OrthoDB; 883628at2759; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Endoplasmic reticulum;
KW   Glycoprotein; Repeat; Secreted; Signal.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   CHAIN        25    361       Cysteine-rich with EGF-like domain
FT                                protein 2-A.
FT                                /FTId=PRO_0000256249.
FT   DOMAIN      134    176       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      191    238       FU 1.
FT   REPEAT      251    298       FU 2.
FT   DOMAIN      288    329       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    303    303       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    352    352       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    138    152       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    146    164       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    166    175       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    292    306       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    299    315       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    317    328       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   361 AA;  39745 MW;  D370C9AE4F00E08D CRC64;
     MNGSRALHLS AWLLLCLLCS AAVARDDSCE TCRKLVDRFH KGLENTAKKN FGGGNTAWEE
     KTLSKYESSE IRLVEIIENL CDSSDFECNH MVEEHEEQIE KWWFKMKKKY PDLLKWFCIE
     TIKVCCPPGT YGPDCLACLG GSERPCHGNG FCNGDGTRSG DGLCRCEAEY TGPFCLECAD
     EYFSSERNDT YSLCTACNQA CKTCDGPSNE DCKECKNGWI KDDGKCVDLN ECASEESPCK
     DSQYCLNTEG SFLCKECDGS CLGCSGEGPE NCKDCATGYV LLAEKCTDVD ECDASEQVCS
     RENETCLNTA GSYKCTCSEG FEDKEGNCVK IMEAENTEVT DGEMGTSASD INISNTAHED
     L
//
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