ID PAXI1_DANRE Reviewed; 943 AA.
AC Q5XIY8;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=PAX-interacting protein 1;
DE AltName: Full=PAX transactivation activation domain-interacting protein;
GN Name=paxip1; ORFNames=zgc:92593;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in DNA damage response. May function as
CC transcriptional cofactor in TGF beta signaling. Accentuates Smad2-
CC dependent transcription (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with smad2 via its last three BRCT domain-containing
CC regions in an activin signal-dependent manner. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC083530; AAH83530.1; -; mRNA.
DR AlphaFoldDB; Q5XIY8; -.
DR SMR; Q5XIY8; -.
DR STRING; 7955.ENSDARP00000113779; -.
DR PaxDb; 7955-ENSDARP00000113779; -.
DR PeptideAtlas; Q5XIY8; -.
DR AGR; ZFIN:ZDB-GENE-041010-214; -.
DR ZFIN; ZDB-GENE-041010-214; paxip1.
DR eggNOG; KOG2043; Eukaryota.
DR InParanoid; Q5XIY8; -.
DR PRO; PR:Q5XIY8; -.
DR Proteomes; UP000000437; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd17714; BRCT_PAXIP1_rpt1; 1.
DR CDD; cd17710; BRCT_PAXIP1_rpt2; 1.
DR CDD; cd17711; BRCT_PAXIP1_rpt3; 1.
DR CDD; cd17730; BRCT_PAXIP1_rpt4; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 4.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR PANTHER; PTHR23196:SF37; PAX-INTERACTING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR SMART; SM00292; BRCT; 4.
DR SUPFAM; SSF52113; BRCT domain; 4.
DR PROSITE; PS50172; BRCT; 4.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..943
FT /note="PAX-interacting protein 1"
FT /id="PRO_0000296264"
FT DOMAIN 8..93
FT /note="BRCT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT DOMAIN 94..182
FT /note="BRCT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT DOMAIN 664..756
FT /note="BRCT 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT DOMAIN 763..851
FT /note="BRCT 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00033"
FT REGION 190..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 730..747
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 190..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 108033 MW; 0EB659817675CD56 CRC64;
MSEDDLKVPE ELFKDVKFYV VGDIDQKVVQ LLKSGKGKEV SYNALATHII AEDGDNPEVG
ESREVFDLPV VKPSWVILSV KCGDLLPVTG FSPESGQVFF GVTACLPHLA EDLNALWAFI
TFYGGDCQLH FNKKCTHLVV PEPKGAKYEC ALRHNNIKIV TPEWILDSVK EKNRKDEMLY
HPRLTLYDAP EEEGSEYENE RSSRSEGSYS DRRSPHSRRS SPTSSRDASP AGRRSPSTKH
ERKSELMFDD SDDSSPEKED RNLNWTPAEV LPPGPAKRRL QPGKETGLIN LCANVPPVPG
SFGPPDARMV GAGAGAGGGV PMGVERLEVM SEWNSAARTL RNITNNTDTQ QPSRPSNVAH
IIQSFSASSK GVVDHMGNQG QSGIPNQLLL KAQQQLPPEA QQQLLQQQQQ QSHQLQQQQQ
QHQMAQQHPM MLPQVMQMHH HQQQQQHQPP PQQQQQQQNQ QGFPQMPPQS HQFLQQQMHQ
QMYSQHQQQQ QQQQQQQQQH AFPQQMRPQQ LPRLPLQHQQ QHVLQQQLQL QQQHRLQLQL
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQKQQQQQQQ NQQQMHQQYL QQQQHFLQQQ
LQQQHMQQLQ QQQQMQQQQQ QHLQNQQPLQ HQNQQVNPHQ TQTMLQPPIT SAQLFGHEPG
HDIPEEGFLV GCIFAIADYP EQMADKQLLA TWKRIIQLNG GTVDSALNRC THLLCESQVS
NTYLQALREG KRCVTAHWLN TVLKKKKMVP PHRTLHLPFS FPPGAKPCAQ HIISVTGFVD
SDRDDLKLMA YLAGARYTGY LCRSNTVLIC KEPSGLKYEK AKEWRIPCVN AQWLCDILLG
NFEALRQIQH SKYTQFNLPD PLAPNHHLVH NLLSAWRIPV KISPEALASL RLQLKQKQAD
VSVQPPSKRP KLEELPTPTK SFHLIQHLTS FSQALNLCRL SST
//
