GenomeNet

Database: UniProt
Entry: Q5XM32
LinkDB: Q5XM32
Original site: Q5XM32 
ID   RXFP2_CANLF             Reviewed;         737 AA.
AC   Q5XM32;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   08-MAY-2019, entry version 99.
DE   RecName: Full=Relaxin receptor 2;
DE   AltName: Full=INSL3 receptor;
DE   AltName: Full=Leucine-rich repeat-containing G-protein coupled receptor 8;
DE   AltName: Full=Relaxin family peptide receptor 2;
GN   Name=RXFP2; Synonyms=LGR8;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White shepherd;
RA   Agoulnik A.I.;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for relaxin. The activity of this receptor is
CC       mediated by G proteins leading to stimulation of adenylate cyclase
CC       and an increase of cAMP. May also be a receptor for Leydig
CC       insulin-like peptide (INSL3) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
DR   EMBL; AY749634; AAU95071.1; -; mRNA.
DR   RefSeq; NP_001005870.1; NM_001005870.1.
DR   STRING; 9612.ENSCAFP00000009735; -.
DR   PaxDb; Q5XM32; -.
DR   GeneID; 450220; -.
DR   KEGG; cfa:450220; -.
DR   CTD; 122042; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; KOG2087; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   HOGENOM; HOG000049056; -.
DR   InParanoid; Q5XM32; -.
DR   KO; K04307; -.
DR   OrthoDB; 559381at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR   GO; GO:0007190; P:activation of adenylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   Gene3D; 4.10.400.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR008112; Relaxin_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01739; RELAXINR.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00369; LRR_TYP; 10.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS51450; LRR; 9.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Leucine-rich repeat;
KW   Membrane; Receptor; Reference proteome; Repeat; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    737       Relaxin receptor 2.
FT                                /FTId=PRO_0000069701.
FT   TOPO_DOM      1    399       Extracellular. {ECO:0000255}.
FT   TRANSMEM    400    420       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM    421    438       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    439    459       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM    460    478       Extracellular. {ECO:0000255}.
FT   TRANSMEM    479    501       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    502    520       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    521    541       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    542    575       Extracellular. {ECO:0000255}.
FT   TRANSMEM    576    596       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    597    622       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    623    643       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    644    653       Extracellular. {ECO:0000255}.
FT   TRANSMEM    654    674       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    675    737       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       27     64       LDL-receptor class A.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   REPEAT      121    142       LRR 1.
FT   REPEAT      145    166       LRR 2.
FT   REPEAT      169    190       LRR 3.
FT   REPEAT      193    214       LRR 4.
FT   REPEAT      217    238       LRR 5.
FT   REPEAT      241    262       LRR 6.
FT   REPEAT      265    286       LRR 7.
FT   REPEAT      289    310       LRR 8.
FT   REPEAT      313    334       LRR 9.
FT   REPEAT      337    358       LRR 10.
FT   CARBOHYD     37     37       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    121    121       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    257    257       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    318    318       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    361    361       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     28     41       {ECO:0000250}.
FT   DISULFID     35     54       {ECO:0000250}.
FT   DISULFID     48     63       {ECO:0000250}.
FT   DISULFID    478    556       {ECO:0000250}.
SQ   SEQUENCE   737 AA;  84109 MW;  2FC61629E851132D CRC64;
     MFPLLHFIVL IDVKDFPLTE GSTITPLCQK GYFPCGNLTK CLPRAFHCDG VDDCGNGADE
     DNCGDTSGWA TIFGTVHGNA NNVALTQECF LNQYPQPCDC KGTELECINA DLRAVPVISS
     NTTLLSLKKN KIHSLPDKVF TKYTQLKQIF LQHNCITHIS RKAFFGLHNL QILYLSHNCI
     TTLRPGVFKD LHQLTWLILD DNPITRISQQ LFTGLKSLFF LSMVNNYLEA LPKQMCAQMP
     QLNWMDLEGN GIKYLTNSSF LSCNSLTVLF LPRNQIDFVP EKTFSSLKNL GELDLSSNMI
     MELPPEIFKD LKLLQKLNLS SNPLLYLHKN QFESLKQLQS LDLERIEIPN INTRMFQPMM
     NLSHIYFKNF RYCSYAPHVR ICMPLTDGIS SFEDLLANNI LRIFVWVIAF ITCFGNLFVI
     GMRSFIKAEN TTHATSIKIL CCADCLMGVY LFFIGFFDIK YRGQYQKYAL LWMESLQCRL
     MGFLAMLSTE VSVLLLTYLT LEKFLAIVFP FSNIRPGKWQ TMVILICIWI VGFLIAVIPF
     WKEDYFGNFY GKNGVCFPLY YDQTEDIGSK GYSLGIFLGV NLLAFLIIVF SYTIMFCSIK
     KTALQTSEVR NPIGREVAVA NRFFFIVFSD AICWIPVFVI KILSLFRVEI PGTITSWIVI
     FFLPVNSALN PILYTLTTSF FKDKLKQLLH KHRRKSIFKT KKKSLSTSIV WTDDSSSLKL
     GVLNKITLGD SIVKPIS
//
DBGET integrated database retrieval system