ID Q5YNA3_NOCFA Unreviewed; 1126 AA.
AC Q5YNA3;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Putative membrane protein {ECO:0000313|EMBL:BAD60338.1};
GN OrderedLocusNames=NFA_54860 {ECO:0000313|EMBL:BAD60338.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD60338.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD60338.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD60338.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AP006618; BAD60338.1; -; Genomic_DNA.
DR RefSeq; WP_011212020.1; NC_006361.1.
DR AlphaFoldDB; Q5YNA3; -.
DR STRING; 247156.NFA_54860; -.
DR GeneID; 61136055; -.
DR KEGG; nfa:NFA_54860; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_8_0_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..379
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 478..700
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 738..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..895
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..941
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1053
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1126 AA; 118285 MW; 0651A04BDC7FB9D0 CRC64;
MFTRWGELVY RFRFAVIGIV AAALLALGGY GFGLENHLSS SGWDDPTSES AQAARIADEA
FGRDHTSDVI VLYTAPEGKT IDDPEFRDKI VDSLNRLPRE HPDEIDKVNG AYWQTETGPG
VPLTFGSKDK KYTFASIAIV GDNDTDMVRN YRKVKDVFYI PGVDVQVTGL QAVAGTLNDT
MASDQKRMEL LAIPAVAVLL FFIFGGLVAA GLPLVVGGLT VIGANGIIMA LTKFTEVNSF
VGGVVSMIGL GLAIDYGLFI VSRFREELAE GYDTPAAVRR SVMTAGRTVV FSATMIVASL
GGMLLFPQGF LKSVAYGTIA TVTLAALTAI TILPAMLGVL GPRVDMLGLK RFRKTKTAEE
VENGFWGKTT QWVMRHPLKI AVPICIVLLL LIIPVKNLAF GGINERYLPP DNKTRVALEN
FYEVFPLKKT DPVQLVMVSE DSAAVGAVWK QASEAPGLVG SFEVPSRSTT QPDVYRTSAT
LEDSENANPT IDYLRSMDVP DSVQLYVGGQ PTIQKDSIDA LLERMPLMIA LVLFVTTLLM
FLTFGSLVLP IKAALMSALG LGSTLGILTW IFVDGHGSGL LNFTPQPIMS PVLVLIIAVI
YGLSTDYEVF LLSRMVEARS MGASTTEAVR AGTAHTGRII TAAALILLVV VGAFAFSDLV
MMQYIAYGLI AALFIDATIL RMLLVPATMK LLGDDCWWAP AWMKRIQERI GLGEPILDDE
RPGGGEVVDL VKTTPVTDPV TMQMPAMPEE KQRKSPRRVR TIEEIEAEAP TQRIEDLPEA
RAKAGKTPPR PRTAMPVAPD PTRPRAHPQP GQEGARPGRP GPASPFQAGS AFQAVPSVDQ
PATGPKQPGH PGKPAGPSGQ SSVPGLGRPL PSRPQPGRSA PAEPQPGPSA QPPHPGGAAA
PKAGGGAPLP GARPAPPRAP GASVGEPTRP QAPPRPARPV GPPGAGGAAV PSGPVQGGHG
PHRAPSGPAD GPSGFAGTPG GPIGPTAGAA GGPSRVPDEP GMRGGPSVAP GGPADPGTPG
TLPAAHGHRP AAEPPPPVPN GPSPAPNGPR HVPNGPDPQD AAATPAGDPV AEHGEGPGDN
RTSIENWMAE LRSSRRRSAG GDEGRHHSGD GRSVSVNELL RRQDEE
//
