ID Q5YPL8_NOCFA Unreviewed; 254 AA.
AC Q5YPL8;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Putative methyltransferase {ECO:0000313|EMBL:BAD59873.1};
GN OrderedLocusNames=NFA_50210 {ECO:0000313|EMBL:BAD59873.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD59873.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD59873.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD59873.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; AP006618; BAD59873.1; -; Genomic_DNA.
DR RefSeq; WP_011211556.1; NC_006361.1.
DR AlphaFoldDB; Q5YPL8; -.
DR STRING; 247156.NFA_50210; -.
DR GeneID; 61135599; -.
DR KEGG; nfa:NFA_50210; -.
DR eggNOG; COG2243; Bacteria.
DR HOGENOM; CLU_098653_0_0_11; -.
DR OrthoDB; 9787471at2; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0043819; F:precorrin-6A synthase (deacetylating) activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11643; Precorrin-6A-synthase; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012797; CobF.
DR NCBIfam; TIGR02434; CobF; 1.
DR PANTHER; PTHR43467; COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR43467:SF1; PRECORRIN-6A SYNTHASE [DEACETYLATING]; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036525; CobF; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:BAD59873.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAD59873.1}.
FT DOMAIN 3..219
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 254 AA; 28150 MW; BD88CE7D1868CD2B CRC64;
MRKLYVIGIG AGDPGQVTMQ AVAAMRQVEV FFVIGKGEQK RELAELRTAI LHAHVDRPYR
VVPIPDPPRD RTPDDYRGVV EDWHERRSLL LEQAFAETGG VGGILVWGDP SLYDSTLRMV
ERVLARGAMR FDYEVIPGIT SAQALAARHR IVLHDIGEPV HITTGRKLRE EGLGPGSTLV
MLDGECSFTT VAEPDVHIWW GAYLGMPDET LIAGPLREVG ERIAAVRARL RDRKGWIMDI
YLLRRSPGNV GAAG
//
